77124-22-2Relevant articles and documents
COMPOUNDS USEFUL AS MODULATORS OF TRPM8
-
Paragraph 0849; 0850, (2016/03/29)
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
Synthesis of α-Methylene β-Lactones, Novel Heterocycles
Adam, Waldemar,Albert, Rainer,Grau, Nuria Dachs,Hasemann, Ludwig,Nestler, Bernd,et al.
, p. 5778 - 5781 (2007/10/02)
Triphenylphosphin deoxygenation of β-alkyl-, β,β-dialkyl-, and β,β-spirocycloalkyl-substituted α-methylene-β-peroxy lactones 3a-k, which are readily available by photooxygenation of the corresponding α,β-unsaturated carboxylic acids 1, and cyclization of the resulting α-methylene-β-hydroperoxy acids 2 constitute a convenient method for the preparation of a variety of α-methylene β-lactones 5.Alternatively, the α-methylene-β-hydroxycarboxylic acids 4 can be directly cyclized by benzenesulfonyl chloride in pyridine into these novel four membered ring heterocycles 5.
Phosphite-Mediated in Situ Carboxyvinylation: A New General Acrylic Acid Synthesis
Brittelli, David R.
, p. 2514 - 2520 (2007/10/02)
Sequential treatment of a 2-halo carboxylic acid with a dialkyl phosphite and an aldehyde or ketone in the presence of 3 equiv of sodium hydride in glyme constitutes a new general acrylic acid synthesis superior to conventional methods.An alkoxide-in-alcohol variant may be used with bromo- or chloroacetic acid and aryl aldehydes to produce cinnamic acids conveniently.The scope and other features of the synthesis are discussed.
