342416-30-2Relevant academic research and scientific papers
Novel cycloalkene indole carbazole alkaloids via the ring closing metathesis reaction
Wilson, Lawrence J.,Yang, Cangming,Murray, William V.
, p. 7399 - 7403 (2007)
Methodology for the synthesis of a series of carbocyclic indole carbazole natural product analogs is presented. The chemistry involves construction of the core indole, followed by attachment of double bond tethered side chains of three and four carbon len
Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses
Wilson, Lawrence J.,Malaviya, Ravi,Yang, Cangming,Argentieri, Rochelle,Wang, Bingbing,Chen, Xin,Murray, William V.,Cavender, Druie
supporting information; experimental part, p. 3333 - 3338 (2010/07/03)
The synthesis and biological evaluation of JAK3 based staurosporine compounds is described. The compounds are constructed completely de novo, and a ring closing metathesis strategy is used to assemble the sugar mimetic portion. These analogs show potent J
Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors
Shen, Lan,Prouty, Catherine,Conway, Bruce R.,Westover, Lori,Xu, Jun Z.,Look, Richard A.,Chen, Xin,Beavers, Mary Pat,Roberts, Jerry,Murray, William V.,Demarest, Keith T.,Kuo, Gee-Hong
, p. 1239 - 1255 (2007/10/03)
Palladium catalyzed cross-coupling reactions were used to synthesize two key intermediates 3 and 5 that resulted in the synthesis of novel series of macrocyclic bis-7-azaindolylmaleimides. Among the three series of macrocycles, the oxygen atom and thiophe
