436867-22-0Relevant academic research and scientific papers
Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors
Shen, Lan,Prouty, Catherine,Conway, Bruce R.,Westover, Lori,Xu, Jun Z.,Look, Richard A.,Chen, Xin,Beavers, Mary Pat,Roberts, Jerry,Murray, William V.,Demarest, Keith T.,Kuo, Gee-Hong
, p. 1239 - 1255 (2004)
Palladium catalyzed cross-coupling reactions were used to synthesize two key intermediates 3 and 5 that resulted in the synthesis of novel series of macrocyclic bis-7-azaindolylmaleimides. Among the three series of macrocycles, the oxygen atom and thiophe
