3425-47-6Relevant academic research and scientific papers
Steroids 54. Amino acylamidosteroids
Vincze, Iren,Hackler, Laszlo,Szendi, Zsuzsa,Schneider, Gyula
, p. 697 - 702 (1996)
Aminosteroids were prepared and acylated with protected amino acids by means of the mixed anhydride or the active ester method. The tert- butyloxycarbonyl-(BOC) protecting group was eliminated by acidolysis, and the benzyloxycarbonyl-(Z) group by catalytic hydrogenation. 3β- and 6β- Glycylamidosteroids were prepared by indirect amination of chloroacetamido derivatives, formed by the Ritter reaction on the corresponding 3α,5α- cyclo and 5α,6α-epoxy steroids. Water soluble double salts were produced from the compounds for pharmacological investigations.
