Steroids 54. Amino acylamidosteroids

Article abstract of DOI:10.1016/S0039-128X(96)00202-4

Aminosteroids were prepared and acylated with protected amino acids by means of the mixed anhydride or the active ester method. The tert- butyloxycarbonyl-(BOC) protecting group was eliminated by acidolysis, and the benzyloxycarbonyl-(Z) group by catalytic hydrogenation. 3β- and 6β- Glycylamidosteroids were prepared by indirect amination of chloroacetamido derivatives, formed by the Ritter reaction on the corresponding 3α,5α- cyclo and 5α,6α-epoxy steroids. Water soluble double salts were produced from the compounds for pharmacological investigations.