3426-08-2Relevant articles and documents
One-pot synthesis of pharmacologically active secondary and tertiary 1- (3,3-diarylpropyl)amines via rhodium-catalysed hydroaminomethylation of 1,1- diarylethenes
Rische, Thorsten,Eilbracht, Peter
, p. 1915 - 1920 (1999)
Pharmacologically active secondary and tertiary 1-(3,3- diarylpropyl)amines 1 are prepared in high yields and chemoselectivity by the reaction of 1,1-diarylethenes 4, primary or secondary amines 5, carbon monoxide and hydrogen in presence of [Rh(cod)Cl]2/PBu3 as catalyst via a one-pot hydroformylation - amine condensation - reduction sequence.
Migratory Arylboration of Unactivated Alkenes Enabled by Nickel Catalysis
Wang, Wang,Ding, Chao,Li, Yangyang,Li, Zheqi,Li, Yuqiang,Peng, Long,Yin, Guoyin
supporting information, p. 4612 - 4616 (2019/03/13)
An unprecedented arylboration of unactivated terminal alkenes, featuring 1,n-regioselectivity, has been achieved by nickel catalysis. The nitrogen-based ligand plays an essential role in the success of this three-component reaction. This transformation displays good regioselectivity and excellent functional-group tolerance. In addition, the incorporation of a boron group into the products provides substantial opportunities for further transformations. Also demonstrated is that the products can be readily transformed into pharmaceutically relevant molecules. Unexpectedly, preliminary mechanistic studies indicate that although the metal migration favors the α-position of boron, selective and decisive bond formation is favored at the benzylic position.
Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation
Li, Shengkun,Huang, Kexuan,Zhang, Jiwen,Wu, Wenjun,Zhang, Xumu
supporting information, p. 1036 - 1039 (2013/04/23)
A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.