4279-81-6Relevant articles and documents
THE PALLADIUM-CATALYZED CONJUGATE ADDITION TYPE REACTION OF ARYL IODIDES WITH α,β-UNSATURATED ALDEHYDES
Cacchi, S.,Torre, F. La,Palmieri, G.
, p. C48 - C52 (1984)
α,β-Enals have been shown to react with aryl iodides in the presence of a palladium catalyst with selective formation of conjugate addition type products.
Rh-catalyzed 1,4-addition reactions of arylboronic acids accelerated by co-immobilized tertiary amine in silica mesopores
Motokura, Ken,Hashiguchi, Kohei,Maeda, Kyogo,Nambo, Masayuki,Manaka, Yuichi,Chun, Wang-Jae
, p. 1 - 9 (2019/05/04)
Mesoporous silica-supported Rh complex catalysts were prepared by simple silane-coupling, followed by complexation, and characterized by FT-IR, SEM, Rh K-edge XAFS, and elemental analysis. Local structures of the Rh complexes in each sample were almost similar to those of a nonporous silica-supported diaminorhodium complex. Co-immobilization of a tertiary amine on the same silica surface induced slight changes to the Rh complex structure in the case of the support with smaller pores. The prepared catalysts showed high activity for the 1,4-addition reaction of phenylboronic acids. Co-immobilization of the tertiary amine increased the reaction rate by more than 7-fold, with turnover number of nearly 8500. The catalytic performance achieved with this novel system is with much higher than that reported previously with a nonporous silica-supported catalyst. The mesoporous silica-supported Rh complex-tertiary amine showed a wide substrate scope, including unsaturated ketones and nitriles. This co-immobilized tertiary amine may activate phenylboronic acid to enhance its reactivity in the transmetalation step with Rh-OH species.
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site
Giraudo, Alessandro,Krall, Jacob,Nielsen, Birgitte,S?rensen, Troels E.,Kongstad, Kenneth T.,Rolando, Barbara,Boschi, Donatella,Fr?lund, Bente,Lolli, Marco L.
supporting information, p. 311 - 321 (2018/09/21)
The correct application of bio(iso)steric replacement, a potent tool for the design of optimized compounds, requires the continuous development of new isosters able to respond to specific target requirements. Among carboxylic acid isosters, as the hydroxy
