342602-55-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone,1-(5-fluoro-3-pyridinyl)is utilized as a crucial building block in the synthesis of a range of drugs and bioactive molecules. Its unique structure allows for the development of compounds with specific therapeutic properties, making it an indispensable component in the creation of novel pharmaceutical agents.
Used in Organic Synthesis:
In the realm of organic synthesis, Ethanone,1-(5-fluoro-3-pyridinyl)serves as a valuable intermediate. Its reactivity and structural features facilitate its involvement in numerous chemical reactions, contributing to the formation of a variety of complex organic compounds.
Used in Agrochemicals and Crop Protection:
Ethanone,1-(5-fluoro-3-pyridinyl)also finds application in the agrochemical sector, where it is employed in the development of compounds for crop protection. Its potential to be incorporated into molecules with pesticidal properties underscores its importance in this field, helping to enhance agricultural productivity and crop safety.

Upstream product

• 342602-54-4 5-fluoro-N-methoxy-N-methylnicotinamide 
• 75-16-1 methylmagnesium bromide 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 1249603-25-5 1-(5-fluoropyridin-3-yl)ethan-1-ol 
• 407-20-5 3-bromo-5-fluoropyridine 

Downstream Products

• 1421922-45-3 4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline 
• 1203709-19-6 2-bromo-1-(5-fluoropyridin-3-yl)ethanone hydrobromide 

Relevant academic research and scientific papers

NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.

Asymmetric Biocatalytic Synthesis of Fluorinated Pyridines through Transesterification or Transamination: Computational Insights into the Reactivity of Transaminases

The synthesis of a family of pyridines bearing a fluorinated substituent on the aromatic ring has been carried out through two independent and highly stereoselective chemoenzymatic strategies. Short chemical synthetic routes toward fluorinated racemic amines and prochiral ketones have been developed, which served as substrates to explore the suitability of lipases and transaminases in asymmetric biotransformations. The lipase-catalyzed kinetic resolution via acylation of racemic amines proceeded smoothly giving conversions close to 50% and excellent enantioselectivities. Alternatively, the biotransamination of the corresponding prochiral ketones was investigated giving access to both optically pure amine enantiomers using transaminases with complementary selectivity. High to quantitative conversion values were achieved, which allowed the isolation of the amines in moderate to high yields (40–88%). A deeper understanding of the latter process was enabled by performing theoretical calculations on thermodynamic and mechanistic aspects. Calculations showed that the biotransamination reactions are highly favoured by the presence of fluorine atoms and the pyridine ring. (Figure presented.).

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.