342616-98-2Relevant academic research and scientific papers
POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
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, (2014/10/04)
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
New potent C2-symmetric malaria plasmepsin I and II inhibitors.
Oscarsson, Karin,Oscarson, Stefan,Vrang, Lotta,Hamelink, Elizabeth,Hallberg, Anders,Samuelsson, Bertil
, p. 1235 - 1246 (2007/10/03)
A series of malaria plasmepsin (Plm) I and II inhibitors containing a C(2)-symmetric core structure have been synthesised and tested for protease inhibition activity. These compounds can be prepared using a straightforward synthesis involving a phenol nuc
Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids
Jones,Fordice,Greenwald,Hannah,Jacobs,Ruyle,Walford,Shen
, p. 1100 - 1104 (2007/10/05)
We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.
