342644-45-5Relevant academic research and scientific papers
Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors
Nam, Ghilsoo,Yoon, Cheol Min,Kim, Euikyung,Rhee, Chung K,Kim, Joong Hyup,Shin, Jung Hyu,Kim, Sung Hoon
, p. 611 - 614 (2001)
The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 5l and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA).
