342649-71-2Relevant academic research and scientific papers
Sphingomyelin analogues as inhibitors of sphingomyelinase
Taguchi, Minoru,Sugimoto, Kikuo,Goda, Ken-Ichi,Akama, Tomoko,Yamamoto, Kyoko,Suzuki, Taizo,Tomishima, Yasumitsu,Nishiguchi, Mariko,Arai, Koshi,Takahashi, Kenzo,Kobori, Takeo
, p. 1963 - 1966 (2003)
To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showed inhibitory activity with an IC50 value of μM on neutral sphingomyelinase in rat brain microsomes. Compound 8i showed a selective neutral sphingomyelinase inhibitory activity.
