34274-11-8Relevant academic research and scientific papers
Direct Synthesis of Enamides via Electrophilic Activation of Amides
Berger, Martin,Kaiser, Daniel,Maulide, Nuno,Spie?, Philipp
supporting information, p. 10524 - 10529 (2021/07/28)
A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.
Asymmetric synthesis of enantiomerically enriched atropisomeric amides by desymmetrisation of N,N-dialkylmesitamides
Clayden, Jonathan,Johnson, Paul,Pink, Jennifer H.
, p. 371 - 375 (2007/10/03)
Asymmetric synthesis of enantiomerically enriched atropisomeric amides was carried out by desymmetrisation of N,N-dialkylmesitamides. Lithiation and silylation of the latter using chiral lithium amide bases was performed. The technique of including an ele
