342777-55-3Relevant academic research and scientific papers
Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994
Aitken, David J.,Ongeri, Sandrine,Vallée-Goyet, Danielle,Gramain, Jean-Claude,Husson, Henri-Philippe
, p. 659 - 661 (2001)
A non-rigid cyclopropane-containing diamine analogue of CP-99,994 was synthesised and was found to have only moderate NK1 receptor binding affinity. Molecular dynamics calculations of the conformational space of the former compound gave good co
