342783-28-2Relevant academic research and scientific papers
Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines
Jana, Sourav,Samanta, Sadhanendu,Bagdi, Avik K.,Shirinian, Valerii Z.,Hajra, Alakananda
, p. 12360 - 12367 (2018/04/12)
A simple and efficient metal-free arylation of imidazo[1,2-a]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.
An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via silver(I)-catalyzed C-H bond functionalization
Khoshneviszadeh, Mehdi,Soheilizad, Mehdi,Fardpour, Maryam,Mahdavi, Mohammad
, p. 1817 - 1821 (2017/09/26)
Abstract: An efficient and economic Ag-catalyzed method for the direct cross-coupling of unactivated imidazo[1,2-a]pyridines with arylboronic acids has been developed. This approach leads to the formation of corresponding 2,3-diarylimidazo[1,2-a]pyridine derivatives as biological and pharmaceutical materials of interest in good yields under mild reaction conditions. Graphical abstract: [Figure not available: see fulltext.].
Synthesis of Disubstituted 3-Phenylimidazo[1,2-a]pyridines via a 2-Aminopyridine/CBrCl3 α-Bromination Shuttle
Roslan, Irwan Iskandar,Ng, Kian-Hong,Wu, Ji'-En,Chuah, Gaik-Khuan,Jaenicke, Stephan
, p. 9167 - 9174 (2016/10/17)
A versatile protocol for the synthesis of disubstituted 3-phenylimidazo[1,2-a]pyridines by coupling 2-aminopyridine with phenylacetophenones, phenylacetones, or β-tetralone has been developed. Isolated yields of up to 97% were obtained at 80 °C within 5 h
Straightforward synthesis of various 2,3-diarylimidazo[1,2-a]pyridines in peg400 medium through one-pot condensation and C-H arylation
Hiebel, Marie-Aude,Fall, Yacoub,Scherrmann, Marie-Christine,Berteina-Raboin, Sabine
, p. 4643 - 4650 (2014/08/05)
PEG400 is described herein as a suitable medium for the condensation of various 2-amino pyridines with α-bromo ketones. 2-Arylimidazo[1,2-a]pyridines were synthetized in a short time through microwave irradiation in moderate to excellent yields
