342800-92-4Relevant academic research and scientific papers
2-Aminoquinazoline inhibitors of cyclin-dependent kinases
Bathini, Yadagiri,Singh, Inderjit,Harvey, Patricia J.,Keller, Paul R.,Singh, Rajeshwar,Micetich, Ronald G.,Fry, David W.,Dobrusin, Ellen M.,Toogood, Peter L.
, p. 3881 - 3885 (2007/10/03)
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.
