342808-49-5Relevant academic research and scientific papers
PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
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Paragraph 0370, (2019/10/23)
The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
Propagation of Enzyme-Induced Surface Events inside Polymer Nanoassemblies for a Fast and Tunable Response
Zhuang, Jiaming,Se?inti, Hatice,Zhao, Bo,Thayumanavan
supporting information, p. 7111 - 7115 (2018/06/15)
We report a new molecular design strategy that allows for the propagation of surface enzymatic events inside a supramolecular assembly for accelerated molecular release. The approach addresses a key shortcoming encountered with many of the currently avail
Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines
Dourlat, Jennifer,Liu, Wang-Qing,Gresh, Nohad,Garbay, Christiane
, p. 2527 - 2530 (2008/02/01)
Novel 1,4-benzodiazepine compounds were synthesized and evaluated for their ability to inhibit the proliferation of tumor cells. Some compounds revealed activities in the micromolar range and were more efficient than reference compound Ro 5-4864. Prelimin
Phosphate prodrugs of isophosphoramide mustard
Misiura, Konrad,Szymanowicz, Daria,Wietrzyk, Joanna,Opolski, Adam
, p. 109 - 112 (2007/10/03)
Dibenzylphosphorobenzyl and phosphorobenzyl analogues of isophosphoramide mustard, an active metabolite of ifosfamide were synthesized. Phosphorobenzyl analogue posseses stronger cytotoxic activity than isophosphoroamide mustard against the cells of sever
