34284-28-1

Basic information

• Product Name: METHYL ACETOACETATE SODIUM SALT
• Synonyms: SODIUM METHYLACETOACETATE;METHYL ACETOACETATE SODIUM SALT;methyl acetoacetate, monosodium salt;Einecs 251-918-5;Methyl acetoacetate sodiuM salt >=97.0% (T)
• CAS NO: 34284-28-1
• Molecular Formula: C₅H₇O₃*Na
• Molecular Weight: 138.1
• EINECS: 251-918-5
• Product Categories: Building Blocks;Carbonyl Compounds;Carboxylic Acid Salts;Chemical Synthesis;Organic Building Blocks
• Mol File: 34284-28-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 216.5°Cat760mmHg
• Flash Point: 92.3°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 2-8°C
• BRN: 4127717
• CAS DataBase Reference: METHYL ACETOACETATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ACETOACETATE SODIUM SALT(34284-28-1)
• EPA Substance Registry System: METHYL ACETOACETATE SODIUM SALT(34284-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10-21
• TSCA: No
• Hazardous Substances Data: 34284-28-1(Hazardous Substances Data)

Usage

General Description

Methyl acetoacetate sodium salt is a chemical compound with the formula CH3COCH2COO-Na+. It is a sodium salt of methyl acetoacetate, which is used as a reagent in organic synthesis. It is a clear, colorless to yellow liquid with a fruity odor, and it is soluble in water and organic solvents. Methyl acetoacetate sodium salt is commonly used as a precursor for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of dyes, pigments, and flavoring agents. Additionally, it is used as a chelating agent and a catalyst in certain chemical reactions.

InChI:InChI=1/C5H8O3.Na/c1-4(6)3-5(7)8-2;/h3,6H,1-2H3;/q;+1/p-1/b4-3-;

Upstream product

• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 4619-66-3 methyl 2-acetylacetoacetate 
• 74053-93-3 methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate 
• 116981-00-1 2-Acetyl-5-oxo-5-phenyl-pentanoic acid methyl ester 
• 91604-70-5 dicarbonyl[methyl (2-5-η-cyclohepta-2,4-dienyl)acetoacetate](triphenylphosphine)iron 
• 91550-82-2 dicarbonyl[methyl (2-5-η-6-methyl-2,4-cycloheptadienyl)acetoacetate](triphenyl phosphite)iron 
• 1736-20-5 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylic acid 
• 59562-43-5 methyl 2-(2,4-dinitrophenyl)-3-oxobutanoate 
• 51756-08-2 methyl 2-ethyl-3-oxobutanoate 
• 74536-45-1 2,3-diacetyl succinic acid dimethyl ester 
• 3666-82-8 2-benzyl-3-oxo-butyric acid methyl ester 
• 41264-06-6 methyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 
• 113895-25-3 methyl 2,4,4-trimethyl-5-methylene-4,5-dihydro-3-furoate 
• 100053-51-8 5-methoxy-2,4,4,5-tetramethyl-4,5-dihydro-furan-3-carboxylic acid methyl ester 
• 52148-91-1 methyl 5-methyl-2,4-hexadienoate 

Relevant articles and documents

Method for synthesizing Fimasartan

The invention discloses a method for synthesizing Fimasartan. The method comprises the steps: subjecting a compound VI and a compound VII to a reaction in toluene, so as to obtain a compound V; subjecting the compound V and pentamidine hydrochloride to a reaction in the presence of alkali metal hydroxide, so as to obtain a compound IV; subjecting the compound IV to hydrogen drawing with lithium hydride in a mixed solvent prepared from toluene and DMF, and then, carrying out an N-alkylation reaction with 2-cyano-4'-bromo-methyl biphenyl, so as to obtain a compound III; subjecting the compound III and sodium azide to a reaction in DMF in the presence of zinc chloride, so as to obtain a compound II; and subjecting the compound II to a thio amidation reaction with a Lawesson's reagent, therebyobtaining the target product I. According to the method, the process is simple, the operation is simple and convenient, the raw materials are readily available, and the method is economical and efficient, so that the production cost of the Fimasartan is greatly reduced, and the industrial production is easy to achieve.

Achieving chemo-, regio-, and stereoselectivity in palladium-catalyzed reaction of γ-borylated allylic acetates

Three-carbon highly functionalized γ-borylated allylic acetates underwent a regio- and stereocontrolled Tsuji-Trost reaction in the presence of palladium complexes. An ipso substitution of the acetate with complete stereoretention of the chiral center was achieved, leading to vinylic boronates with enantiomeric excesses above 99%.