34284-28-1

Basic information

• Product Name: METHYL ACETOACETATE SODIUM SALT
• Synonyms: SODIUM METHYLACETOACETATE;METHYL ACETOACETATE SODIUM SALT;methyl acetoacetate, monosodium salt;Einecs 251-918-5;Methyl acetoacetate sodiuM salt >=97.0% (T)
• CAS NO: 34284-28-1
• Molecular Formula: C₅H₇O₃*Na
• Molecular Weight: 138.1
• EINECS: 251-918-5
• Product Categories: Building Blocks;Carbonyl Compounds;Carboxylic Acid Salts;Chemical Synthesis;Organic Building Blocks
• Mol File: 34284-28-1.mol

Chemical Properties

• Boiling Point: 216.5°Cat760mmHg
• Flash Point: 92.3°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 2-8°C
• BRN: 4127717
• CAS DataBase Reference: METHYL ACETOACETATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ACETOACETATE SODIUM SALT(34284-28-1)
• EPA Substance Registry System: METHYL ACETOACETATE SODIUM SALT(34284-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10-21
• TSCA: No
• Hazardous Substances Data: 34284-28-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl acetoacetate sodium salt is used as a precursor in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, this sodium salt is utilized as a starting material for the production of different agrochemicals, aiding in the creation of products that enhance crop protection and yield.
Used in Dye and Pigment Manufacturing:
Methyl acetoacetate sodium salt is employed in the manufacturing process of dyes and pigments, playing a role in the creation of colorants for various applications, including textiles, plastics, and printing inks.
Used in Flavor and Fragrance Industry:
As a component in the production of flavoring agents, this sodium salt contributes to the development of flavors and fragrances for the food, beverage, and cosmetic industries.
Used as a Chelating Agent:
Methyl acetoacetate sodium salt serves as a chelating agent in certain chemical processes, helping to bind and stabilize metal ions, which is crucial in various industrial applications.
Used as a Catalyst:
In some chemical reactions, METHYL ACETOACETATE SODIUM SALT functions as a catalyst, facilitating and accelerating the reaction process without being consumed in the overall reaction.

InChI:InChI=1/C5H8O3.Na/c1-4(6)3-5(7)8-2;/h3,6H,1-2H3;/q;+1/p-1/b4-3-;

Upstream product

• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 41264-06-6 methyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 
• 3666-82-8 2-benzyl-3-oxo-butyric acid methyl ester 
• 51756-08-2 methyl 2-ethyl-3-oxobutanoate 
• 4619-66-3 methyl 2-acetylacetoacetate 
• 59562-43-5 methyl 2-(2,4-dinitrophenyl)-3-oxobutanoate 
• 42996-87-2 2-acetyl-5-(4-methoxy-phenyl)-3-oxo-pent-4-enoic acid methyl ester 
• 2382-59-4 2-methyl-3-oxobutanoic acid 
• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 172159-95-4 methyl 3-oxo-2-(3'-acetyl)phenylbutanoate 
• 172159-94-3 methyl 3-oxo-2-(4'-acetyl)phenylbutanoate 
• 116981-00-1 2-Acetyl-5-oxo-5-phenyl-pentanoic acid methyl ester 
• 91604-70-5 dicarbonyl[methyl (2-5-η-cyclohepta-2,4-dienyl)acetoacetate](triphenylphosphine)iron 
• 91604-73-8 dicarbonyl[methyl (2-5-η-cyclohepta-2,4-dienyl)acetoacetate](triphenyl phosphite)iron 
• 91550-82-2 dicarbonyl[methyl (2-5-η-6-methyl-2,4-cycloheptadienyl)acetoacetate](triphenyl phosphite)iron 

Relevant articles and documents

Method for synthesizing Fimasartan

The invention discloses a method for synthesizing Fimasartan. The method comprises the steps: subjecting a compound VI and a compound VII to a reaction in toluene, so as to obtain a compound V; subjecting the compound V and pentamidine hydrochloride to a reaction in the presence of alkali metal hydroxide, so as to obtain a compound IV; subjecting the compound IV to hydrogen drawing with lithium hydride in a mixed solvent prepared from toluene and DMF, and then, carrying out an N-alkylation reaction with 2-cyano-4'-bromo-methyl biphenyl, so as to obtain a compound III; subjecting the compound III and sodium azide to a reaction in DMF in the presence of zinc chloride, so as to obtain a compound II; and subjecting the compound II to a thio amidation reaction with a Lawesson's reagent, therebyobtaining the target product I. According to the method, the process is simple, the operation is simple and convenient, the raw materials are readily available, and the method is economical and efficient, so that the production cost of the Fimasartan is greatly reduced, and the industrial production is easy to achieve.

Pheromone synthesis. Part 259: Synthesis of seven methyl-branched hydrocarbons as the pheromone candidates for female Korean apricot wasp, Eurytoma maslovskii

Seven new methyl-branched hydrocarbons were synthesized, which were the pheromone candidates of the female Korean apricot wasp (Eurytoma maslovskii). They are (Z)-15-methyl-7-nonacosene (1), (Z)-17-methyl-7-hentriacontene (2), 3,7-dimethylheptacosane (3), 8,12-dimethyltriacontane (4), 8,18-dimethyltriacontane (5), 3,7,11-trimethylnonacosane (6), and 3,7,17-trimethylnonacosane (7). All of them were synthesized as stereoisomeric mixtures, employing short and simple routes. Hydrocarbon 7 was synthesized via 4,8-dimethyldecanal (71, tribolure), the red flour beetle pheromone. The hydrocarbons 1,2,3 and 6 were identified by GC–MS analysis as the components (with unknown stereochemistry) of the female-specific secretion of E. maslovskii.

Achieving chemo-, regio-, and stereoselectivity in palladium-catalyzed reaction of γ-borylated allylic acetates

Three-carbon highly functionalized γ-borylated allylic acetates underwent a regio- and stereocontrolled Tsuji-Trost reaction in the presence of palladium complexes. An ipso substitution of the acetate with complete stereoretention of the chiral center was achieved, leading to vinylic boronates with enantiomeric excesses above 99%.

PYRAZOLE COMPOUNDS AND USE THEREOF

The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.