4619-66-3

Usage

Uses

Used in Pharmaceutical Industry:
Methyl diacetoacetate is used as a pharmaceutical intermediate for its role in the synthesis of various medicinal compounds. Its reactivity allows for the creation of new pharmaceuticals that can address a range of health conditions.
Used in Organic Synthesis:
In the realm of organic synthesis, Methyl diacetoacetate is utilized as a reagent, contributing to the development of new chemical entities with potential applications across different industries.
Used in Flavor and Fragrance Industry:
Methyl diacetoacetate is employed as a component in the production of flavoring and fragrance compounds, capitalizing on its slightly fruity odor to enhance or create scents for various products.
Used in Polymer and Resin Production:
This chemical compound is also used in the manufacture of certain polymers and resins, where its properties contribute to the formation of materials with specific characteristics required for various applications.
Overall, Methyl diacetoacetate's diverse applications underscore its importance in multiple sectors, highlighting its versatility and value as a chemical intermediate and reagent.

InChI:InChI=1/C7H10O4/c1-4(8)6(5(2)9)7(10)11-3/h6H,1-3H3

Upstream product

• 4525-27-3 β-acetoxy-crotonic acid methyl ester 
• 463-51-4 Ketene 
• 105-45-3 acetoacetic acid methyl ester 
• 34284-28-1 sodium methyl acetoacetate 
• 75-36-5 acetyl chloride 
• 67-56-1 methanol 
• 60700-15-4 3-acetyl-(3H,5H)-tetrahydrothiophene-2,4-dione 
• 124-38-9 carbon dioxide 
• 123-54-6 acetylacetone 
• 74-88-4 methyl iodide 

Downstream Products

• 123-54-6 acetylacetone 
• 1041464-57-6 methyl 3,5-dimethyl-1(4-sulfamoylphenyl)-1H-pyrazole-4-carboxylate 
• 1255639-37-2 Methoxycarbonyl-curcumin 
• 73773-25-8 methyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Ambient carboxylation on a supported reversible CO2 carrier: Ketone to β-keto ester

A reversible CO2 carrier (RCC) has been developed to perform carboxylation of ketone to β-ketoester under ambient CO2 pressure and temperature. RCC has been synthesized by immobilizing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) on methylhydrosiloxane support and reacting with CO2 with 100% degree of functionalisation. RCC is found to be recyclable and shows retention of activity in 5 recycles. CO2 absorption under ambient temperature and desorption at 120°C renders the material suitable for carrying out carboxylation reactions at 25°C with excellent yields. The yield of the reaction can reach up to 100% with TON 200 in 4 h. The extent of the reaction primarily depends upon enol content of the substrate. β-Ketoacid produced during the reaction can be isolated and converted to its corresponding methyl ester derivative by reacting with methyl iodide.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

Cycloaddition of cross-conjugated trienes to halogenated quinones

The chemoselectivity of [4+2] cycloadditions involving electron-rich cross-conjugated trienes and halogenated quinones has been examined. The approach provides improved preparations of 6-acetyl-2,3,7-trihydroxyjuglone, solorinic and norsolorinic acids, and averythrin. It also confirms the structure proposed for haematommone and 3,8-dihydroxy-4-methoxy-2-methoxycarbonyl-1-methylanthraquinone but invalidates that of sopheranin.