342896-04-2

Upstream product

• 141-52-6 sodium ethanolate 
• 105-67-9 2,4-Xylenol 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 64965-91-9 5,7-dimethylbenzofuran 
• 1026689-02-0 4-[4-(5,7-dimethyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 1370283-16-1 C₁₉H₁₉N₃O₃S 
• 1370283-21-8 C₁₉H₁₉N₃O₂S₂ 
• 134671-58-2 2-(2,4-DIMETHYLPHENOXY)ACETALDEHYDE 
• 67962-68-9 2C₁₁H₁₆N₄O*H₂O₄S 

Relevant academic research and scientific papers

Direct Dimesitylborylation of Benzofuran Derivatives by an Iridium-Catalyzed C?H Activation with Silyldimesitylborane

Direct dimesitylborylation of benzofuran derivatives by a C?H activation catalyzed by an iridium(I)/N-heterocyclic carbene (NHC) complex in the presence of Ph2MeSi-BMes2 afforded the corresponding dimesitylborylation products in good to high yield with excellent regioselectivity. This method provides a straightforward route to donor–(π-spacer)–acceptor systems with intriguing solvatochromic luminescence properties.

The synthesis of some new hydrazone derivatives containing the benzothiazole moiety

Hydrazones are an important class of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of a new series of ten compounds based on the coupling of 2-oxo-3(2H)-benzothiazoleacetic acid, hydrazide and 2-thioxo-3(2H)- -benzothiazoleacetic acid, hydrazide with different aldehydes. The structures of the synthesized compounds were confirmed by elemental analyses, IR, 1H- -NMR, 13C-NMR and FAB+-MS spectral data. Copyright 2012 (CC) SCS.

Discovery of novel and potent retinoic acid receptor α agonists: Syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives

In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and synthesized a series of benzofuran and benzothiophene derivatives. Some of these compounds (1a,b,e,f,j) markedly inhibited LPS- induced B-lymphocyte proliferation and exerted RARα selectivity. One of them, 4-[5-(4,7-dimethylbenzofuran-2-yl)pyrrol-2-yl]benzoic acid (1b), when orally administered significantly inhibited mouse antibody production and delayed type hypersensitivity (DTH) responses from a dose of 0.1 mg/kg.

Bronchodilator and Antiulcer Phenoxypyrimidinones

Series of 5-phenoxy-2(1H)-pyrimidinones, 5-phenoxy-4(3H)-pyrimidinones, and related compounds were prepared in a follow-up of a lead prepared as a potential cyclic nucleotide regulating agent.Compounds were evaluated for bronchodilator activity in histamine-challenged guinea pigs and for antiulcer activity in a cold-restraint, stressed rat ulcer model.Bronchodilator activity comparable to, or greater than, that of theophylline was found in both the 2(1H)- and 4(3H)-pyrimidinone series and was most prominent in analogues containing either an electron-withdrawing or -donating substituent in the para position of the phenoxy ring.Significant antiulcer activity was observed only in the 2(1H)-pyrimidinone series among three closely related analogues.One of these, 5-(m-methylphenoxy)-2(1H)-pyrimidinone (3), exhibited more potent antiulcer effects than the clinically useful antiulcer agent carbenoxolone, without demonstrating bronchodilator activity.