342897-32-9Relevant academic research and scientific papers
Design and synthesis of new orally active inhibitors of human neutrophil elastase
Ohmoto, Kazuyuki,Okuma, Motohiro,Yamamoto, Tetsuya,Kijima, Hideomi,Sekioka, Tomohiko,Kitagawa, Kanji,Yamamoto, Shigeki,Tanaka, Kenji,Kawabata, Kazuhito,Sakata, Atsushi,Imawaka, Haruo,Nakai, Hisao,Toda, Masaaki
, p. 1307 - 1323 (2007/10/03)
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n showed more potent inhibitory activity than nonpeptidic derivatives 3a-c. As a result, a series of peptidic inhibitors, 4a-s a
