34297-84-2

Usage

InChI:InChI=1/C12H8N2O/c1-2-4-9(5-3-1)12-14-10-8-13-7-6-11(10)15-12/h1-8H

Upstream product

• 15590-89-3 3-aminopyrid-4-one 
• 93-97-0 benzoic acid anhydride 
• 104621-57-0 N-(4-hydroxypyridin-3-yl)benzamide 
• 6320-39-4 3-aminopyridin-4-ol 
• 140-29-4 phenylacetonitrile 
• 3454-03-3 nitrate 4-hydroxypyridine 
• 15590-90-6 3-nitro-4(1H)-pyridinone 
• 5435-54-1 4-hydroxy-3-nitropyridine 
• 65-85-0 benzoic acid 

Downstream Products

• 34282-21-8 4-ethyl-2-phenyl-oxazolo[4,5-c]pyridine 

Relevant academic research and scientific papers

Iron-Catalyzed Sulfur-Promoted Decyanative Redox Condensation of o-Nitrophenols and Arylacetonitriles: An Unprecedented Route to 2-Arylbenzoxazoles

Elemental sulfur in the presence of a catalytic amount of FeCl2·4H2O was found to be highly efficient for the promotion of decyanative redox condensation reactions of o-nitrophenols with arylacetonitriles, to give a wide range of 2-arylbenzoxazoles. The utility of elemental sulfur was highlighted by its role as cyanide scavenger and external reducing agent.

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.

New facile and mild synthesis of 2-substituted oxazolopyridines

A new, two-step synthesis of oxazolopyridines is described. The synthesis involving amide formation between o-aminopyridinols and aliphatic or aromatic carboxylic acids followed by condensation with hexachloroethane/ triphenylphosphine takes place at room

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.