34308-10-6 Usage
Type
Synthetic nucleoside analogue
Antiretroviral Properties
Yes
Usage
Treatment of HIV/AIDS as part of combination therapy
Mechanism of Action
Inhibits the replication of the HIV virus by being incorporated into the viral DNA, leading to chain termination and inhibition of viral replication
Type of Analogue
Thymidine analogue
Toxicities
Peripheral neuropathy and lactic acidosis
Current Recommendation
No longer recommended as a first-line treatment for HIV/AIDS due to its adverse effects
Check Digit Verification of cas no
The CAS Registry Mumber 34308-10-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,3,0 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 34308-10:
(7*3)+(6*4)+(5*3)+(4*0)+(3*8)+(2*1)+(1*0)=86
86 % 10 = 6
So 34308-10-6 is a valid CAS Registry Number.
34308-10-6Relevant articles and documents
A facile method for deprotection of trityl ethers using column chromatography
Pathak, Ashish K.,Pathak, Vibha,Seitz, Lainne E.,Tiwari, Kamal N.,Akhtar, Mohammad S.,Reynolds, Robert C
, p. 7755 - 7757 (2007/10/03)
A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds with only slight alterations in the procedure. Nineteen examples are given.
A mild and efficient method for the deprotection of tert-butyldimethylsilyl ethers using iodine in methanol
Vaino, Andrew R.,Szarek, Walter A.
, p. 2351 - 2352 (2007/10/03)
An effective method for the cleavage of tert-butyldimethylsilyl ethers using a 1% solution of iodine in methanol is described.
