343221-63-6

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 554-00-7 2,4-Dichloroaniline 
• 1452-94-4 ethyl 2-chloronicotinate 
• 115800-79-8 ethyl 2-(2,4-dichloro anilino)nicotinate 

Downstream Products

• 1350515-61-5 N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(2,4-dichlorophenyl)amino]-3-pyridinecarboxamide 
• 1350515-68-2 N-3-[6-(nitro-1,3-benzothiazol-2-yl)]-2-[(2,4-dichlorophenyl)amino]-3-pyridinecarboxamide 
• 1350515-73-9 2-[2-(2,4-dichloroanilino)-3-pyridyl]-10-methyl-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione 
• 1350515-77-3 2-[2-(2,4-dichloroanilino)-3-pyridyl]-10-phenyl-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione 
• 1393658-13-3 N₃-(6-fluoro-1,3-benzothiazol-2-yl)-2-(2,4-dichloroanilino)nicotinamide 
• 136280-60-9 (2,4-Dichloro-phenyl)-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 127555-33-3 1-(2,4-dichlorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo[2,3-b]pyridin-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents

A series of nicotinic acid derivatives structurally related to niflumic acid and certain pyridazine-containing compounds have been synthesized and characterized by analytical and spectral data. All compounds were screened for their potential analgesic and

2-ANILINO NICOTINYL LINKED 2-AMINO BENZOTHIAZOLE CONJUGATES AND PROCESS FOR THE PREPARATION THEREOF

The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1═H or CI; R2═H, OCH3 or F; R3═H, OCH3, F or CI; R4═H, OCH3 or F and X═OCH3, F or N02.

Synthesis of 2-(arylamino)nicotinic acids in high-temperature water

In hydrothermal reactions at 150-180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%). Springer Science+Business Media B.V. 2012.

2-ANILINO NICOTINYL LINKED 2-AMINO BENZOTHIAZOLE CONJUGATES AND PROCESS FOR THE PREPARATION THEREOF

The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1 = H or CI; R2 = H, OCH3 or F; R3 = H, OCH3, F or CI; R4=H, OCH3 or F and X= OCH3, F or N02.

Catalyst-free amination of 2-chloronicotinic acid in water under microwave irradiation

A simple, efficient and environmental friendly method for the synthesis of 2-arylaminonicotinic acids derivatives by reacting 2-chloronicotinic acid with anilines with potassium carbonate as the base and water as the media under microwave irradiation is described. The synthesis of 2-arylaminonicotinic acids is important because they are nonsteroidal anti-inflammatory drugs.

2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers

A series of N-(2-anilino-pyridyl) linked 2-amino benzothiazoles (4a-n) and [1,2,4]triazolo [1,5-b]benzothiadiazine conjugates (5a-j) have been designed, synthesized and evaluated for their antiproliferative activity. Some of these compounds (4h-k, 4n, and

Substituted 1,3-Dihydro-2H-pyrrolopyridin-2-ones as Potential Antiinflammatory Agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolopyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR).Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin- and leukotriene-derived products or arachidonic acid metabolism although these compounds exhibit no significant inhibitory activity against the cyclooxygenase and 5-lipoxygenase enzymes in vitro.Structure-activity relationships in this series are discussed.