343223-65-4Relevant academic research and scientific papers
Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
Li, Xiangqian,Liang, Xiaomeng,Song, Ting,Su, Pengchen,Zhang, Zhichao
, p. 5738 - 5746 (2015/02/02)
We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
Van Der Walt, Mietha M.,Terre'Blanche, Gisella,Petzer, Anél,Petzer, Jacobus P.
supporting information, p. 6632 - 6635 (2013/01/14)
Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative diseases, respectively. Base
