6941-75-9

Basic information

• Product Name: 4-Bromophthalimide
• Synonyms: bromophtalimide;5-bromoisoindole-1,3-dione;5-BROMO PHTHALIMIDE;4-BROMOPHTHALIMIDE;4-Bromophtalimide;4-BROMOPHTHALIMIDE 98+%;1H-Isoindole-1,3(2H)-dione, 5-broMo-;4-BroMophthaliMide, 97+%
• CAS NO: 6941-75-9
• Molecular Formula: C₈H₄BrNO₂
• Molecular Weight: 226.03
• Product Categories: Heterocycles
• Mol File: 6941-75-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 235 °C
• Appearance: Off-white/Solid
• Density: 1.826g/cm³
• Refractive Index: 1.649
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in N,N-DMF almost transparency.
• PKA: 9.19±0.20(Predicted)
• CAS DataBase Reference: 4-Bromophthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromophthalimide(6941-75-9)
• EPA Substance Registry System: 4-Bromophthalimide(6941-75-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 6941-75-9(Hazardous Substances Data)

Usage

Chemical Properties

yellow to slight yellow powder

Uses

It is used as a intermediate for pharmaceutical and organic synthesis.

InChI:InChI=1/C8H4BrNO2/c9-4-1-2-5-6(3-4)8(12)10-7(5)11/h1-3H,(H,10,11,12)

Upstream product

• 583-71-1 4-bromo-o-xylene 
• 67832-11-5 4-bromo-2-methylbenzonitrile 
• 85-44-9 phthalic anhydride 

Downstream Products

• 127168-84-7 5-bromoisoindoline 
• 919346-89-7 5-bromo-2,3-dihydro-1H-isoindole hydrochloride 
• 90224-73-0 5-bromo-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione 
• 1356116-29-4 methyl 5-bromo-2-((methoxycarbonyl)amino)benzoate 
• 1356116-26-1 methyl 4-bromo-2-((methoxycarbonyl)amino)benzoate 
• 1431567-12-2 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(methylsulfonamidomethyl)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide 
• 1431567-17-7 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-((N-(2-morpholinoethyl)-methylsulfonamido)-methyl)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide 
• 343223-65-4 5-(phenylthio)isoindoline-1,3-dione 
• 64146-72-1 5-(p-tolylthio)isoindoline-1,3-dione 
• 86-90-8 4-bromophthalic anhydride 
• 368441-44-5 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate 
• 149353-71-9 2-(tert-butoxycarbonyl)isoindoline-5-carboxylic acid 
• 253801-14-8 tert-butyl 5-(hydroxymethyl)-1,3-dihydro-2H-isoindole-2-carboxylate 

Relevant articles and documents

Dihydroxyphenyl Sulfonylisoindoline Derivatives

Provided are compounds that are inhibitors of pyruvate dehydrogenase kinase (PDK), and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Industrial preparation method of 5-bromophthalide

The invention relates to a preparation method of 5-bromophthalide and mainly solves such production technical problems of an existing preparation method as expensive raw material, dangerous and complex operation, relatively low yield, high quantity of generated three wastes and etc. The technical scheme of the invention is as follows: an industrial preparation method of 5-bromophthalide is characterized in that 5-bromophthalide is obtained through three step reactions of bromination, ammoniation and reduction by taking a conventional and easily available ammoniation as a raw material. The chemical reaction formula is as shown in the description. The method provided by the invention is mainly used for industrial preparation of 5-bromophthalide.

Kinetics of oxidative ammonolysis of 4-bromo-o-xylene: V. Synthesis of 4-bromophthalonitrile

Oxidative ammonolysis of 4-bromo-o-xylene on a V-Sb-Bi-Zr/γ-Al 2O3 catalyst gives 74.82 mol % of 4-bromophthalonitrile at a high conversion of the starting xylene in a one-cycle process. The process with recirculation results in decreased number of by-products and contribution of deep oxidation and increased selectivity in 4-bromophthalonitrile up to 95.42-96.58%.