343223-86-9

Upstream product

• 343232-82-6 carbethoxy-6 chloro-7 phenyl-1 pyrazolo <4,3-b> pyridine 
• 343230-84-2 carbethoxy-6 phenyl-1 pyrazolo <4,3-b> pyridine 
• 1128-53-6 1-phenyl-1H-pyrazol-4-amine 

Downstream Products

• 77763-16-7 (phenyl-1 pyrazolo <4,3-b> pyridyl)-6 aminomethylene malonate d'ethyle 
• 77763-05-4 9-Oxo-1-phenyl-6,9-dihydro-1H-pyrazolo[3,4-f][1,7]naphthyridine-8-carboxylic acid ethyl ester 
• 77763-06-5 9-Oxo-1-phenyl-6,9-dihydro-1H-pyrazolo[3,4-f][1,7]naphthyridine-8-carboxylic acid 
• 77763-10-1 amino-6 phenyl-1 pyrazolo <4,3-b> pyridine 
• 343223-85-8 carbamoyl-6 phenyl-1 pyrazolo <4,3-b> pyridine 

Relevant academic research and scientific papers

Synthesis of methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates and their conversion to tert-butyl 4,5,6,7-tetrahydropyrazolo-[4,3-b]pyridine-6-carboxylates

[Figure not available: see fulltext.] N-Boc-4-aminopyrazole-5-carbaldehydes react with methyl 3,3-dimethoxypropanoate or β-keto esters in acetic acid under reflux to form methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates, which were converted to the corresponding tert-butyl carboxylates via intermediate carboxylic acids. Their subsequent hydrogenation on a 10% Pd/C catalyst at 100°C and 25 atm afforded tert-butyl 4,5,6,7-tetrahydropyrazolo[4,3-b]pyridine-6-carboxylates.

Nouveaux agents antibacteriens II. Derives pyrazolo-azaquinoleiniques

New pyrazolonaphtyridine carboxylic acids were synthesized and tested as antibacterial agents.Some of them are active against Gram positive strains in vitro but are ineffective against Gram negative strains tested, contrary to nalidixic and pipemidic acid