1128-53-6

Basic information

• Product Name: 1-Phenyl-1H-pyrazol-4-amine
• Synonyms: 1-Phenyl-1H-pyrazol-4-amine
• CAS NO: 1128-53-6
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.19
• Mol File: 1128-53-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 104-105 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 305.4°C at 760 mmHg
• Flash Point: 138.5°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.000822mmHg at 25°C
• Refractive Index: 1.641
• PKA: 4.45±0.10(Predicted)
• CAS DataBase Reference: 1-Phenyl-1H-pyrazol-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1H-pyrazol-4-amine(1128-53-6)
• EPA Substance Registry System: 1-Phenyl-1H-pyrazol-4-amine(1128-53-6)

Safety Data

• Hazardous Substances Data: 1128-53-6(Hazardous Substances Data)

Usage

General Description

1-Phenyl-1H-pyrazol-4-amine, also known as phenazone, is a chemical compound with the molecular formula C10H10N4. It is a synthetic derivative of pyrazole and is often used as an analgesic and antipyretic medication. Phenazone works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation and pain. It is commonly used to relieve mild to moderate pain, such as headaches, dental pain, and muscle aches. Phenazone is available in various forms, including tablets, capsules, and as a component in combination drugs. It is generally considered safe when used as directed, but like any medication, it can have potential side effects and interactions with other drugs.

InChI:InChI=1/C9H9N3/c10-8-6-11-12(7-8)9-4-2-1-3-5-9/h1-7H,10H2

Upstream product

• 3994-48-7 4-nitro-1-phenylyrazole 
• 108-86-1 bromobenzene 
• 28466-26-4 4-aminopyrazole 
• 591-50-4 iodobenzene 
• 15115-52-3 4-bromo-1-phenyl-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 19218-70-3 mesoxalaldehyde tris-phenylhydrazone 
• 25503-12-2 1-phenyl-4-phenylazo-1H-pyrazole 

Downstream Products

• 405548-29-0 tert-butyl (1-phenyl-1H-pyrazol-4-yl)carbamate 

Relevant articles and documents

Identification and Biological Evaluation of Novel Type II B-RafV600E Inhibitors

The mitogen-activated protein kinase (MAPK) pathway plays a vital role in signal transduction networks. Severe diseases may be triggered if it is disturbed by mutated components, especially the kinase B-RafV600E. New inhibitors of the kinase ar

Design and synthesis of anti-tumor compounds containing ferulic acid-pyrazole skeleton

The invention discloses design and a preparation method of an anti-tumor compound containing a ferulic acid-pyrazole skeleton. The structure of the anti-tumor compound is shown as a formula in the specification.

Cu-Catalyzed Couplings of Heteroaryl Primary Amines and (Hetero)aryl Bromides with 6-Hydroxypicolinamide Ligands

A family of 6-hydroxypicolinamide ligands have been identified as effective supporting ligands for Cu-catalyzed couplings of heteroaryl bromides and chlorides with heteroaryl primary amines. The C-N couplings are carried out at 80-120 °C in DMSO or sulfolane using K2CO3 or K3PO4 as the base with 2-10 mol % CuI and supporting ligand. The strength of the base was found to have an impact on the chemoselectivity and rate. The use of K2CO3 as the base enabled selective C-N coupling of aryl bromides over aryl chlorides with 2-5 mol % Cu at 80-120 °C. With K3PO4 as the base, aryl chlorides are capable of undergoing C-N coupling, though 5-10 mol % Cu is required at 120-130 °C. Members of the ligand family are straightforward to prepare in one step from 6-hydroxypicolinic acid and the corresponding anilines.