343229-18-5Relevant academic research and scientific papers
Regioselectivity in the Addition of Singlet and Triplet Carbenes to 1,1-Dimethylallene. A Probe for Carbene Multiplicity
Creary, Xavier
, p. 1611 - 1618 (1980)
Singlet carbenes add preferentially to the more substituted bond of 1,1-dimethylallene (1), to give methylenecyclopropanes 3 as the major product.In contrast, many triplet carbenes add with differing regioselectivity, giving the thermodynamically preferre
Ring-Opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1 H-Pyrazoles Using Lewis Acid
Panda, Subhankar,Pradhan, Nirmalya,Manna, Debasis
supporting information, p. 573 - 578 (2018/09/25)
An unusual transformation of indoles to pyrazoles via an aromatic ring-opening strategy has been developed. The salient feature of this strategy involves the C2-N1 bond opening and concomitant cyclization reaction of the C2=C3 bond of the indole moiety with the tosylhydrazone, which proceeds under transition-metal and ligand free conditions. This ring-opening functionalization of indoles provides a wide scope of differently substituted pyrazoles.
Palladium-Catalyzed Intermolecular Carbene Insertion Prior to Intramolecular Heck Cyclization: Synthesis of 2-Arylidene-3-aryl-1-indanones
Arunprasath, Dhanarajan,Muthupandi, Pandi,Sekar, Govindasamy
supporting information, p. 5448 - 5451 (2015/11/18)
A domino process that converges the migratory insertion of carbene with a Heck reaction has been established as a versatile tool for the synthesis of 2-arylidene-3-aryl-1-indanones from very stable and easily accessible N-tosylhydrazones and 2′-iodochalco
An efficient one-pot synthesis of 3,5-disubstituted 1H-pyrazoles
Wu, Lei-Lei,Ge, Yi-Cen,He, Ting,Zhang, Lei,Fu, Xing-Li,Fu, Hai-Yan,Chen, Hua,Li, Rui-Xiang
experimental part, p. 1577 - 1583 (2012/06/29)
An efficient, general, one-pot, three-component procedure for the preparation of 3,5-disubstituted 1H-pyrazoles via condensation of substituted aromatic aldehydes, tosylhydrazine and terminal alkynes in toluene is reported. The reaction tolerates a variety of functional groups and sterically hindered substrates to afford the desired pyrazoles in yields of 67-91%.
