343240-59-5Relevant academic research and scientific papers
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers
Lloyd, John,Finlay, Heather J.,Vacarro, Wayne,Hyunh, Tram,Kover, Alexander,Bhandaru, Rao,Yan, Lin,Atwal, Karnail,Conder, Mary Lee,Jenkins-West, Tonya,Shi, Hong,Huang, Christine,Li, Danshi,Sun, Huabin,Levesque, Paul
body text, p. 1436 - 1439 (2010/07/02)
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.
Dihydropyrazolopyrimidine Inhibitors of KV1.5 (IKur)
Vaccaro, Wayne,Huynh, Tram,Lloyd, John,Atwal, Karnail,Finlay, Heather J.,Levesque, Paul,Conder, Mary Lee,Jenkins-West, Tonya,Shi, Hong,Sun, Lucy
experimental part, p. 6381 - 6385 (2009/09/06)
A series of dihydropyrazolopyrimidine inhibitors of KV1.5 (IKur) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.
Heterocyclic dihydropyrimidine compounds
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, (2008/06/13)
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
