343251-08-1

Basic information

• Product Name: (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester
• CAS NO: 343251-08-1
• Molecular Weight: 516.765
• Mol File: 343251-08-1.mol

Chemical Properties

• CAS DataBase Reference: (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester(343251-08-1)
• EPA Substance Registry System: (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester(343251-08-1)

Safety Data

• Hazardous Substances Data: 343251-08-1(Hazardous Substances Data)

Upstream product

• 195823-89-3 R-2-nonyl-succinic acid 4-t-butyl ester 

Downstream Products

• 343251-11-6 (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid 

Relevant articles and documents

Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1)

Structure-activity relationships are described for a series of succinyl hydroxamic acids 4a-O as potent and selective inhibitors of matrix metalloprotease-3 (stromelysin-1). Optimisation of P1′ and P3′ groups gave compound 4j (MMP-3 IC50 = 5.9 nM) which was >140-fold less potent against MMP-1 (IC50 = 51,000 nM), MMP-2 (IC50 = 1790 nM), MMP-9 (IC50 = 840 nM) and MMP-14 (IC50 = 1900 nM).