343254-50-2Relevant academic research and scientific papers
Synthesis of phosphorylated and sulfated glycosyl serines in the linkage region of the glycosaminoglycans
Tamura,Nishihara
, p. 3074 - 3083 (2001)
We synthesized novel acidic glycans having acidic groups located in the linkage region of the glycosaminoglycans (GAGs). The targeted compounds, β-D-Xyl(2P)-Ser (1), β-D-Gal(±6S)-(1→4)-β-D-Xyl(2P)-Ser (3 and 2), β-D-Gal(±6S)-(1→3)-β-D-Gal- (1→4)-β-D-Xyl(2P)-Ser (5 and 4), and β-D-Gal-(1→3)-β-D-Gal(6S)-(1→4)-β-D-Xyl(2P)-Ser (6) contain phosphate and/or sulfate at the specified positions. Some of them (3, 5, and 6) are the first synthesized examples of natural-type glycoconjugates that simultaneously possess phosphate and sulfate as well as carboxylic acid.
