343315-27-5Relevant academic research and scientific papers
Host-guest inclusion system of glycyrrhetic acid with polyamine-β-cyclodextrin: Preparation, characterization, and anticancer activity
Shen, Zhi,Qin, Qi,Liao, Xiali,Yang, Bo
, p. 155 - 161 (2017)
The inclusion complexation behaviors of glycyrrhetic acid (CTA) with four polyamine-modified β-cyclodextrins (CDs) have been investigated by 1H and 2D NMR, thermal gravimetric analysis, X-ray power diffraction and scanning electron microscopy. The results showed that Glycyrrhetic acid was encapsulated into the cavity of cyclodextrin to form the complexes with 1:1 stoichiometry. The water solubility of GTA was significantly enhanced by inclusion complexation with polyamine-modified β-cyclodextrins. The calculated IC50 values indicated that the antitumor activities of inclusion complexes were better than that of GTA. Satisfactory aqueous solubility, along with high thermal stability of inclusion complexes will be potentially useful for their application on the formulation design of natural medicine.
A facile synthesis of a highly water-soluble and selective fluorescent sensor towards zinc ions derived from β-cyclodextrin based on an unexpected sensing process
Liu, Zengchen,Yang, Weijie,Li, Yanxia,Tian, Fengshou,Zhu, Wenping
, p. 100482 - 100487 (2015/12/05)
A highly water-soluble and sensitive fluorescent sensor derived from β-cyclodextrin with relatively lower toxicity was synthesized. The fluorescent sensor exhibited spherical morphology under SEM observation. By the fluorescence behavior towards several m
