343351-67-7 Usage
Uses
Used in Cancer Treatment:
NSC697923 is used as a therapeutic agent for the treatment of neuroblastoma, a type of cancer commonly imaged in the context of the nervous system. It exhibits potent cytotoxicity in a panel of neuroblastoma cell lines, effectively blocking their proliferation and survival.
Additionally, NSC697923 is used as a therapeutic agent for the treatment of diffuse large B-cell lymphoma (DLBCL), particularly the activated B cell-like (ABC-DLBCL) and germinal center B cell-like (GCB-DLBCL) subtypes. It inhibits the proliferation and survival of both ABC-DLBCL and GCB-DLBCL cell lines, as well as the survival of primary DLBCL cells.
References
1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668
2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427
3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718
4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079
Check Digit Verification of cas no
The CAS Registry Mumber 343351-67-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,3,5 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 343351-67:
(8*3)+(7*4)+(6*3)+(5*3)+(4*5)+(3*1)+(2*6)+(1*7)=127
127 % 10 = 7
So 343351-67-7 is a valid CAS Registry Number.
