34339-62-3

Upstream product

• 61278-06-6 methyl 2,3-dideoxy-α-D-erythro-hexopyranoside 
• 98-59-9 p-toluenesulfonyl chloride 
• 2873-29-2 D-glucal triacetate 
• 23339-17-5 methyl 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hexopyranoside 
• 3427-20-1 methyl 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-enopyranoside 

Downstream Products

• 92413-84-8 Toluene-4-sulfonic acid (2R,3S,6S)-6-methoxy-3-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl ester 
• 92413-85-9 methyl-4-O-(t-butyldiphenylsilyl)-2,3-dideoxy-6-O-p-toluenesulfonyl-α-D-erythro-hexopyranoside 

Relevant academic research and scientific papers

CARBON-CARBON BOND FORMATION USING PRIMARY TOSYLATES DERIVED FROM CARBOHYDRATES

Primary tosylates derived from carbohydrates proved to be substrates for direct carbon-carbon bond formation.This procedure is compared to a classical three steps sequence: oxidation-Wittig reaction-hydrogenation.

Synthetic aminoglycosides

Novel pseudotrisaccharides based on 2-deoxy- and 2,5-dideoxystreptamine are described. The compounds of the invention can be considered as modified Kanamycin, Gentamycin and Apramycin compounds. In particular they are deoxy derivatives especially at the 2', 3', 4', 2", 3" and/or 4" and/or possibly at the 6' or 6" positions. The compounds are active bactericides some of which are more active than Kanamycin. It is a particular advantage of the compounds that they are active against Kanamycin resistant bacteria. Methods of making these compounds are also described based on glycosylation reaction from corresponding monosaccharide compounds.