3435-56-1

Basic information

• Product Name: Propanedioic acid, [[4-(dimethylamino)phenyl]methylene]-, diethyl ester
• CAS NO: 3435-56-1
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.347
• Mol File: 3435-56-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [[4-(dimethylamino)phenyl]methylene]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [[4-(dimethylamino)phenyl]methylene]-, diethyl ester(3435-56-1)
• EPA Substance Registry System: Propanedioic acid, [[4-(dimethylamino)phenyl]methylene]-, diethyl ester(3435-56-1)

Safety Data

• Hazardous Substances Data: 3435-56-1(Hazardous Substances Data)

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 105-53-3 diethyl malonate 
• 29751-63-1 2-ethoxy-2-oxoethyl propionate 
• 57806-78-7 p-dimethylamino-1-(dichloromethyl)benzene 

Downstream Products

• 23270-31-7 <α-(O.O-Diaethyl-phosphono)-4-dimethylamino-benzyl>-malonsaeure-diaethylester 
• 1442466-70-7 ethyl 5,6-dihydro-7-(4-dimethylaminophenyl)-5-oxo-2-sulfamoyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-6-carboxylate 
• 77094-95-2 diethyl 2-(4-(dimethylamino)phenyl)cyclopropane-1,1-dicarboxylate 
• 7496-26-6 3-(4-(dimethylamino)phenyl)-2-(4-nitrophenyl)acrylonitrile 
• 16532-81-3 4-(1-cyano-2-(4-(dimethylamino)phenyl)vinyl)benzonitrile 
• 86726-58-1 2-Chloro-2-(4-dimethylamino-benzyl)-malonic acid diethyl ester 
• 86733-89-3 5-(4-Dimethylamino-benzyl)-thiazolidine-2,4-dione 
• 156641-31-5 2--naphtho-<2,1-b>-2,3-dihydropyran-4-one 

Relevant articles and documents

Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors

A series of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives were prepared to evaluate their ability of inhibiting neuraminidase (NA) of influenza A virus. All the compounds were synthesized in good yields starting from aldehyde by using a suitable synthetic strategy, which showed moderate inhibitory activity against influenza A NA. Compound 6g exhibited the strongest inhibitory activity against influenza virus A NA (IC50 = 17.64 μM), which indicated pyrimidine ring could be used as a core structure to design novel influenza NA inhibitors.

Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6- tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates

A series of ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a- carboxylates were prepared through the metal-catalyzed domino reaction of alkylidene malonates and 1,4-butynediol under a one-pot reaction condition at room temperature. Their in vitro anti-proliferative activities were subsequently evaluated in A549, QGY and HeLa cells. The majority of the compounds showed potent anti-tumor activity against HeLa cells. In particular, compound 3l was the most potent compound with IC50 value of 5.4 μM. For the first time, the X-ray structure of the anti-tumor ethyl 3-aryl-4-oxo-3,3a,4,6- tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates is determined.

A practical Knoevenagel condensation catalyzed by PEG400 and anhydrous K2CO3 without solvent

Knoevenagel condensation of aromatic aldehydes with active methylene compounds under solvent-free conditions to synthesize arylidene compounds in good to excellent yields using powdered anhydrous K2CO3 and PEG400 as catalysts has bee