343604-31-9

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde is used as a key intermediate in the synthesis of new drugs due to its unique structural features and reactivity. It contributes to the development of pharmaceuticals with enhanced properties and therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde serves as a crucial component in the creation of novel agrochemicals. Its incorporation aids in the development of more effective and environmentally friendly products for agricultural applications.
Used in Organic Material Synthesis:
5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde is utilized as a building block for the synthesis of various organic materials. Its unique structure allows for the creation of materials with improved characteristics, such as enhanced stability, reactivity, or specific functional properties.
Used in Medicinal Chemistry:
5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde is employed in medicinal chemistry as a versatile compound for the construction of complex molecules with potential therapeutic applications. Its structural features and reactivity make it an attractive candidate for the development of new drugs with desirable properties.
Used in Material Science:
In the field of material science, 5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde is used to create innovative materials with unique properties. Its incorporation into material compositions can lead to advancements in areas such as electronics, coatings, and other high-tech applications.

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 1060548-16-4 2,6-bis[5-(4-trifluoromethylphenyl)thiophene-2-yl]benzo[1,2-d:4,5-d']bisthiazole 
• 115933-15-8 2-(4-(trifluoromethyl)phenyl)thiophene 
• 476155-31-4 {5-[4-(trifluoromethyl)phenyl]thiophen-2-yl}methanol 
• 476155-77-8 3-methyl-5-(4-trifluoromethyl-phenyl)-thiophene-2-carbaldehyde 
• 1026647-48-2 (E)-3-[5-(4-trifluoromethylphenyl)-2-thienyl]acrylic acid chloride 
• 952710-34-8 8-methoxy-1-methyl-3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 952709-95-4 7-methoxy-3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin 
• 952709-94-3 {3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Blue light absorbing material, preparation method and application thereof, and blue light preventing lens

The invention provides a blue light absorbingmaterial, a preparation method and application thereof, and a blue light preventing lens, and relates to the technical field of organic light absorption materials. The invention provides a blue light absorbing

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Ligand-less palladium-catalyzed direct 5-arylation of thiophenes at low catalyst loadings

Ligand-less Pd(OAc)2 provides a very efficient catalyst for the direct 5-arylation of thiophene derivatives. With this catalyst, a low palladium concentration (0.1-0.001 mol%) should be employed in order to obtain high yields of coupling products. At higher concentrations a fast formation of inactive "Pd black" generally occurs. Substrates/catalysts ratios up to 100000 can be employed with the most reactive aryl bromides. A very wide variety of functional groups is tolerated on both coupling partners. The major waste of this reaction is HBr associated with KOAc. Therefore this procedure is more economically and environmentally attractive than the traditional cross-coupling procedures employing organometallic derivatives.

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndr

Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by arylthienylacryloyl-aminobenzophenones

We recently described two novel aryl binding sites of farnesyltransferase. The 4- and 5-arylsubstituted thienylacryloyl moieties turned out as appropriate substituents for our benzophenone-based AAX-peptidomimetic capable for occupying the far aryl binding site.

THIOPHENE DERIVATIVE PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.