343609-94-9Relevant academic research and scientific papers
Identification and biological characterization of 6-aryl-7- isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain
Culshaw, Andrew J.,Bevan, Stuart,Christiansen, Martin,Copp, Prafula,Davis, Andrew,Davis, Clare,Dyson, Alex,Dziadulewicz, Edward K.,Edwards, Lee,Eggelte, Hendrikus,Fox, Alyson,Gentry, Clive,Groarke, Alex,Hallett, Allan,Hart, Terance W.,Hughes, Glyn A.,Knights, Sally,Kotsonis, Peter,Lee, Wai,Lyothier, Isabelle,McBryde, Andrew,McIntyre, Peter,Paloumbis, George,Panesar, Moh,Patel, Sadhana,Seiler, Max-Peter,Yaqoob, Mohammed,Zimmermann, Kaspar
, p. 471 - 474 (2006)
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may have utility in the treatment of chronic nociceptive
