343626-01-7

Upstream product

• 97628-87-0 benzyl (4-aminobutyl)(3-(((benzyloxy)carbonyl)amino)propyl)carbamate 
• 181484-31-1 (7-azido-heptanoylamino)-benzyloxy-acetic acid 
• 181484-26-4 methyl [(7-azidoheptanoyl)amino](benzyloxy)acetate 
• 181483-85-2 7-azidoheptanamide 

Downstream Products

• 343626-02-8 benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate 
• 85468-01-5 deoxyspergualin trihydrochloride 

Relevant academic research and scientific papers

A new efficient synthesis of the immunosuppressive agent (±)-15-deoxyspergualin

(±)-15-Deoxyspergualin is a new promising immunosuppressive agent, recently marketed in Japan for the control of cortico-resistant acute renal graft rejection. We describe here a nine-step synthesis starting from 7-bromoheptanenitrile and N1,N4-bis(benzyloxycarbonyl)spermidine, suitable for the production of multigram quantities of this unstable highly polar compound with an 18% overall yield. Furthermore, it opens the way for the synthesis of α-hydroxyglycine analogues.