34366-21-7

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-3-(PIPERIDIN-2-YL)PYRIDINE is used as a key building block for the development of various pharmaceuticals. Its unique structure and properties allow it to be a valuable component in the creation of new medications, contributing to advancements in the field of healthcare.
Used in Organic Compound Synthesis:
In addition to its pharmaceutical applications, (R)-3-(PIPERIDIN-2-YL)PYRIDINE is also utilized as a fundamental component in the synthesis of a range of organic compounds. Its versatility and structural characteristics make it an essential tool for researchers and chemists working on the development of novel organic substances.
Used in Chemical Research:
The study of (R)-3-(PIPERIDIN-2-YL)PYRIDINE is not limited to its practical applications; it also serves as an important subject in chemical research. Understanding its properties, interactions, and potential reactions can lead to new insights and discoveries in the broader field of chemistry.

Upstream product

• 1966-44-5 rac-N-methylanabasine 
• 154874-91-6 tert-butyl 2-(pyridine-3-yl)piperidine-1-carboxylate 

Downstream Products

• 1424330-12-0 C₂₂H₂₂Cl₂N₄O₂ 

Relevant academic research and scientific papers

Application of catalytic dynamic resolution of N-Boc-2-lithiopiperidine to the asymmetric synthesis of 2-aryl and 2-vinyl piperidines

The highly enantioselective synthesis of 2-aryl-and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.

Stereoselectivity of the demethylation of nicotine piperidine homologues by Nicotiana plumbaginifolia cell suspension cultures

The metabolism of (R,S)-N-methylanabasine and (R,S)-N-methylanatabine has been studied in a cell suspension culture of Nicotiana plumbaginifolia. Both substrates are effectively demethylated, anabasine or anatabine, respectively, accumulating in the medium. Similarly, there is strong stereoselectivity for the (R)-isomers of both substrates. The kinetics of metabolism of (R,S)-N-methylanabasine differ significantly from those of nicotine in that no further degradation of the initial demethylation product occurs. (R,S)-N-Methylanatabine, however, shows kinetics closer to those of nicotine, with loss of alkaloid from the system. Furthermore, (R,S)-N-methylanabasine does not diminish (S)-nicotine demethylation, indicating a lack of competition. However, the metabolism of (S)-nicotine is affected by the presence of (R,S)-N-methylanabasine. Hence, the demethylation of the piperidine homologues of nicotine is seen to be similar but not identical to that of the pyridine analogues. The implications of these different metabolic profiles in relation to the demethylation activity are discussed.