343781-41-9

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-4-iodopyridine, 97% is used as a key building block for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows for the development of new and innovative medications with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical industry, 3,5-Dichloro-4-iodopyridine, 97% is utilized as a key component in the synthesis of crop protection chemicals. Its incorporation into these products helps to enhance crop yield and protect against pests and diseases.
Used in Organic Synthesis:
3,5-Dichloro-4-iodopyridine, 97% is used as a reagent in organic synthesis, specifically for the preparation of biologically active compounds. Its unique properties enable the creation of new and effective compounds with potential applications in various fields.

InChI:InChI=1/C5H2Cl2IN/c6-3-1-9-2-4(7)5(3)8/h1-2H

Upstream product

• 5439-04-3 3,4,5-trichloropicolinic acid 
• 2457-47-8 3,5-dichloropyridine 
• 846045-08-7 3,5-dichloro-4-hydroxy-pyridine-2-carboxylic acid 
• 200711-45-1 3,4,5-trichloro-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 1370286-84-2 3-(4-chlorophenyl)-N'-(3,5-dichloropyridin-4-yl)propanehydrazide 
• 1370286-85-3 N'-(3,5-dichloropyridin-4-yl)-3-p-tolylpropanehydrazide 
• 1370286-86-4 N'-(3,5-dichloropyridin-4-yl)-3-(4-methoxyphenyl)propanehydrazide 
• 1370286-87-5 2-(4-chlorophenyl)-N'-(3,5-dichloropyridin-4-yl)acetohydrazide 
• 1370286-88-6 2-(2,4-dichlorophenyl)-N'-(3,5-dichloropyridin-4-yl)-acetohydrazide 
• 1370286-89-7 N'-(3,5-dichloropyridin-4-yl)-3-(4-hydroxyphenyl)propanehydrazide 
• 1370286-91-1 N'-(3,5-dichloropyridin-4-yl)benzohydrazide 
• 1370286-92-2 N'-(3,5-dichloropyridin-4-yl)-2-phenylacetohydrazide 
• 1370286-78-4 N'-(3,5-dichloropyridin-4-yl)-4-phenylbutanehydrazide 
• 1370286-93-3 N'-(3,5-dichloropyridin-4-yl)-5-phenylpentanehydrazide 
• 1370286-94-4 N'-(3,5-dichloropyridin-4-yl)-6-phenylhexanehydrazide 
• 1370286-95-5 N'-(3,5-dichloropyridin-4-yl)-7-phenylheptanehydrazide 
• 1370286-96-6 benzyl 2-(3,5-dichloropyridin-4-yl)hydrazinecarboxylate 
• 1370286-97-7 N-benzyl-2-(3,5-dichloropyridin-4-yl)hydrazinecarboxamide 

Relevant academic research and scientific papers

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Deprotonative metalation of chloro- and bromopyridines using amido-based bimetallic species and regioselectivity-computed CH acidity relationships

A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal combinations. Whereas lithium-zinc and lithium-cadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithium-copper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.

Deprotonation of chloropyridines using lithium magnesates

Chloropyridines are deprotonated using lithium magnesates. 4-Chloropyridine was deprotonated on treatment with 1/3 equiv of the highly coordinated magnesate Bu3(TMP)MgLi2 in THF at -10°C, as evidenced by trapping with I2. The use of Bu(TMP)2MgLi in Et 2O allowed the reaction of 2-chloropyridine, giving the 3-functionalized derivative as the main product. Mixtures of 3- and 4-functionalized derivatives were obtained when 2,6-dichloropyridine was involved in the reaction. Performing the reaction on 3-chloropyridine with lithium magnesates in THF, either the 4,4′-dimer or the 4-iodo derivative was formed after quenching by I2, the former using 1/3 equiv of Bu2(TMP)MgLi and the latter using 1 equiv of (TMP)3MgLi. Similar results were observed with 3,5-dichloropyridine, 2,5-dichloropyridine and 3-chloro-2-fluoropyridine. 1,2-Migration of the lithium arylmagnesate formed by deprotonation was proposed to justify the dimers formation.

Strategies for the selective functionalization of dichloropyridines at various sites

Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.