343852-60-8

Upstream product

• 42086-64-6 trans-2-phenylcyclopentan-1-ol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 285-67-6 Cyclopentene oxide 
• 100-58-3 phenylmagnesium bromide 
• 100-59-4 phenylmagnesium chloride 
• 60895-01-4 3(S)-acetoxy-5-(R)-hydroxy-cyclopent-1-ene 
• 414869-14-0 (1S,2S)-2-Phenyl-cyclopent-3-enol 
• 825-54-7 cyclopent-1-en-1-ylbenzene 

Downstream Products

• 825-54-7 cyclopent-1-en-1-ylbenzene 
• 1198-34-1 2-Phenylcyclopentanone 
• 1485-98-9 1,2-diphenylcyclopent-1-ene 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 746564-13-6 (1R,2R)-(-)-cis-2-Phenylcyclopentanamin 

Relevant academic research and scientific papers

p-Toluenesulfonic acid catalysed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centres

A p-toluenesulfonic acid catalyzed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centers has been developed, featuring a broad substrate scope, environmentally benign reaction conditions, and operational simplicity.

Construction of a chiral quaternary carbon center by catalytic asymmetric alkylation of 2-arylcyclohexanones under phase-transfer conditions

In this paper, we present an asymmetric alkylation of modified 2-arylcyclohexanones that employs a novel chiral ammonium bromide as a phase-transfer catalyst and an achiral auxiliary as a controller to improve the enantioselectivity to afford optically enriched products having a chiral quaternary carbon center.

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Screening of the Roche compound library led to the identification of cis-N-(2-phenyl-cyclohexyl)-spiropiperidine 1 as structurally novel GlyT1 inhibitor. The SAR, which was developed in this series, resulted in the discovery of highly potent compounds displaying excellent selectivity against the GlyT2 isoform.

Palladium-catalyzed reaction of 4-cyclopentene-1,3-diol monoacetate with Grignard reagents producing hitherto unreachable cis-1,2-isomers

Reaction of 4-cyclopentene-1,3-diol monoacetate with RMgCl (R = alkyl, aryl) in the presence of a palladium catalyst proceeded with retention of configuration to give cis-1,2-regio-isomers as the major products.

Evidence for the formation of a new five-membered ring cyclic allene: Generation of 1-cyclopenta-1,2-dien-1-ylbenzene

Treatment of 1-(2-iodocyclopent-1-en-1-yl) benzene (13), dissolved in benzene, with potassium t-butoxide resulted in the formation of 1-(2-phenylcyclopent-1-en-1-yl) benzene (15) and 1-cyclopent-1-en-1-yl benzene (5) in a ratio of 1:1.