34403-37-7

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2-pyridinylmethyl)-
• CAS NO: 34403-37-7
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• Mol File: 34403-37-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-pyridinylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-pyridinylmethyl)-(34403-37-7)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-pyridinylmethyl)-(34403-37-7)

Safety Data

• Hazardous Substances Data: 34403-37-7(Hazardous Substances Data)

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 85-44-9 phthalic anhydride 
• 4377-33-7 2-chloromethylpyridine 
• 136918-14-4 phthalimide 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 
• 35854-47-8 N-((pyridin-2-yl)methyl)benzamide 
• 1332749-16-2 3,4-diphenyl-2-(pyridin-2-ylmethyl)isoquinolin-1(2H)-one 

Relevant articles and documents

Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement

An alkoxide-catalyzed hydrosilylation of cyclic imides to isoquinolines was realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence of a base catalyst, and then the carbonyl reduction, followed by siloxy elimination.

Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.

7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors

The invention relates in general to 7,9-dihydro-purin-8-one and related compounds that show broad utility, e.g., in inhibiting heat shock protein 90 (HSP90) to thereby treat or prevent HSP90-mediated diseases.