1332749-16-2

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 35854-47-8 N-((pyridin-2-yl)methyl)benzamide 
• 501-65-5 diphenyl acetylene 
• 98-88-4 benzoyl chloride 
• 34403-37-7 (2-methyl-pyridinyl)-2,3-dihydro-3-oxo-1H-isoindol-1-one 
• 85-44-9 phthalic anhydride 

Downstream Products

• 93119-96-1 3,4-diphenyl-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Visible Light Induced Bifunctional Rhodium Catalysis for Decarbonylative Coupling of Imides with Alkynes

Transition metal catalyzed decarbonylation offers a distinct synthetic strategy for new chemical bond formation. However, the π-backbonding between CO π* orbitals and metal center d-orbitals impedes ligand dissociation to regenerate the catalyst under mild reaction conditions. Developed here is visible light induced rhodium catalysis for decarbonylative coupling of imides with alkynes under ambient conditions. Initial mechanistic studies suggest that the rhodium complex simultaneously serves as the catalytic center and photosensitizer for decarbonylation. This visible light promoted catalytic decarbonylation strategy offers new opportunities for reviewing old transformations with ligand dissociation as a rate-determining step.

Method for preparing polysubstituted isoquinolinone derivative

The invention relates to a method for preparing a polysubstituted isoquinolinone derivative. Specifically, the polysubstituted isoquinolinone derivative is prepared from anhydride, amine and alkyne through a one-pot method under the condition of cobalt catalysis. The polysubstituted isoquinolinone derivative is prepared from simple and easily available raw materials and a catalyst through condensation and cyclization reactions.

Cobalt-catalyzed cyclization of benzamides with alkynes: A facile route to isoquinolones with hydrogen evolution

The reaction of benzamides with alkynes assisted by an 8-aminoquinoline ligand in the presence of Co(OAc)2·4H2O and pivalic acid under an air atmosphere provided isoquinolone derivatives in good to excellent yields. In this reaction,

Benchtop Delivery of Ni(cod)2 using Paraffin Capsules

A facile method that allows for Ni(cod)2 to be used on the benchtop is reported. The procedure involves the preparation of paraffin-Ni(cod)2 capsules, which are stable to air and moisture. It is demonstrated that these readily available capsules can be used to promote a range of Ni(cod)2-catalyzed transformations. These studies are expected to promote the further use of Ni(cod)2 in organic synthesis.

Nickel-catalyzed chelation-assisted transformations involving ortho C-H bond activation: Regioselective oxidative cycloaddition of aromatic amides to alkynes

Although the pioneering example of ortho metalation involving cleavage of C-H bonds was achieved using a nickel complex (Kleiman, J. P.; Dubeck, M. J. Am. Chem. Soc. 1963, 85, 1544), no examples of catalysis using nickel complexes have been reported. In this work, the Ni-catalyzed transformation of ortho C-H bonds utilizing chelation assistance, such as oxidative cycloaddition of aromatic amides with alkynes, has been achieved.