34404-27-8

Basic information

• Product Name: BOC-L-DAB(BOC)
• Synonyms: BOC-L-DAB(BOC);(S)-2,4-BIS-TERT-BUTOXYCARBONYLAMINO-BUTYRIC ACID;(S)-2,4-Bis((tert-butoxycarbonyl)aMino)butanoic acid;Butanoic acid, 2,4-bis[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-;(2S)-2,4-Bis(tert-butoxycarbonylamino)butanoic acid;(S)-2,4-Bis(Boc-amino)butanoic acid;(2S)-2,4-bis[(2-methylpropan-2-yl)oxycarbonylamino]butanoicacid
• CAS NO: 34404-27-8
• Molecular Formula: C₁₄H₂₆N₂O₆
• Molecular Weight: 318.37
• Mol File: 34404-27-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-L-DAB(BOC)(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-DAB(BOC)(34404-27-8)
• EPA Substance Registry System: BOC-L-DAB(BOC)(34404-27-8)

Safety Data

• Hazardous Substances Data: 34404-27-8(Hazardous Substances Data)

Usage

General Description

BOC-L-DAB(BOC) is a chemical compound consisting of the amino acid BOC-L-DAB(BOC). It is commonly used as a building block for synthesizing peptide-based drugs and other bioactive molecules. BOC-L-DAB(BOC) is a derivative of L-DAB(BOC) and belongs to the BOC-protected group of amino acids. It serves as a stable and versatile intermediate for the solid-phase synthesis of peptides, with the BOC group providing protection for the amino group during the reaction steps. BOC-L-DAB(BOC) is important in the field of medicinal chemistry and drug development, as it is essential for the creation of peptide-based therapeutics and molecular probes for biological studies.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1758-80-1 L-2,4-diaminobutyrate 
• 924630-61-5 2-chloro-4-[methoxycarbonyl-(1-phenyl-ethyl)-amino]-butyric acid methyl ester 
• 1482-98-0 L-2,4-diaminobutyric acid monohydrochloride 
• 13726-85-7 Boc-Gln-OH 

Downstream Products

• 1482-98-0 (S)-2,4-diaminobutyric acid dihydrochloride 
• 1112459-54-7 C₃₉H₄₂ClN₇O₇S₂ 

Relevant articles and documents

Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 μmol/L.

Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids

Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNAladdering experiments.

Relationship between Taste and Structure of O-Aminoacyl Sugars Containing Basic Amino Acids

To study the relationship between taste and structure of O-aminoacyl sugars, a number of O-aminoacyl sugars containing basic amino acids were prepared.Taste quality of O-aminoacyl sugars was dependent on the side chain length of basic amino acids that were introduced into sugars.O-Aminoacyl sugars had an excellent sodium ion diet effect that could reduce sodium ion intake to 10 percent.