34404-27-8

Usage

Uses

Used in Pharmaceutical Industry:
BOC-L-DAB(BOC) is used as a building block for synthesizing peptide-based drugs and other bioactive molecules. Its role in the synthesis process is crucial for the development of new therapeutic agents with potential applications in treating various diseases and conditions.
Used in Medicinal Chemistry Research:
BOC-L-DAB(BOC) is used as a key intermediate in the solid-phase synthesis of peptides, enabling the development of novel peptide-based therapeutics and molecular probes for biological studies. Its stability and versatility make it an essential component in the design and synthesis of bioactive peptides and related compounds.
Used in Drug Development:
BOC-L-DAB(BOC) is utilized in the development of new drugs, particularly in the area of peptide-based therapeutics. Its protective BOC group ensures the successful synthesis of peptides with desired properties, contributing to the advancement of drug discovery and innovation.

Upstream product

• 1758-80-1 L-2,4-diaminobutyrate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1482-98-0 L-2,4-diaminobutyric acid monohydrochloride 
• 13726-85-7 Boc-Gln-OH 
• 924630-61-5 2-chloro-4-[methoxycarbonyl-(1-phenyl-ethyl)-amino]-butyric acid methyl ester 

Downstream Products

• 1112459-54-7 C₃₉H₄₂ClN₇O₇S₂ 
• 1482-98-0 (S)-2,4-diaminobutyric acid dihydrochloride 

Relevant academic research and scientific papers

Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 μmol/L.

COMPOUND HAVING READ-THROUGH ACTIVITY

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids

Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNAladdering experiments.

Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner.

Relationship between Taste and Structure of O-Aminoacyl Sugars Containing Basic Amino Acids

To study the relationship between taste and structure of O-aminoacyl sugars, a number of O-aminoacyl sugars containing basic amino acids were prepared.Taste quality of O-aminoacyl sugars was dependent on the side chain length of basic amino acids that were introduced into sugars.O-Aminoacyl sugars had an excellent sodium ion diet effect that could reduce sodium ion intake to 10 percent.