3441-41-6

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 4-chlorophenyl ester
• Synonyms: thiophene-2-carboxylic acid-(4-chloro-phenyl ester);Thiophen-2-carbonsaeure-(4-chlor-phenylester);Thiophene-2-carboxylic acid 4-chloro-phenyl ester;Thiophen-3-carbonsaeure-<4-chlor-phenylester>;Thiophen-2-carbonsaeure-<4-chlorphenylester>
• CAS NO: 3441-41-6
• Molecular Formula: C11H7ClO2S
• Molecular Weight: 238.694
• Mol File: 3441-41-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 82 - 83 °C (hexane)
• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 4-chlorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 4-chlorophenyl ester(3441-41-6)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 4-chlorophenyl ester(3441-41-6)

Safety Data

• Hazardous Substances Data: 3441-41-6(Hazardous Substances Data)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 106-48-9 4-chloro-phenol 
• 91059-63-1 4-nitrophenyl 2-thiophenecarboxylic acid ester 
• 527-72-0 2-thiophenylcarboxylic acid 

Downstream Products

• 97035-11-5 C₁₃H₁₀ClNO₃S 
• 97034-92-9 (5-Chloro-2-hydroxy-phenyl)-thiophen-2-yl-methanone oxime 
• 97035-59-1 5-chloro-2-hydroxyphenyl-2-thienylmethanone 

Relevant articles and documents

Reactions of aryl 5-substituted-2-thiophenecarboxylates promoted by 4-Z-C6H4O-/4-Z-C6H4OH in 20 mol % DMSO(aq). Effect of nucleophile on acyl-transfer reaction

Nucleophilic substitution reactions of 5-XC4H2(S)C(O)OC6H3-2-Y-4-NO2 (1) promoted by 4-Z-C6H4O-/4-Z-C6H4OH in 20 mol % dimethyl sulfoxide (DMSO)(aq) have been studied kinetically. The reactions exhibited second-order kinetics with βacyl = -2.52 to -2.83, ρ(x) = 2.81-3.16, βnuc = 0.88-0.04 and βlg = -0.94, respectively. The results have been interpreted with an addition-elimination mechanism in which the nucleophilic attack occurs in the rate-determining step. Comparison with existing data reveals that the ratedetermining step changes from the second to the first step by the change in the nucleophile from R2NH/R2NH2+ to 4-Z-C6H4O-/4-Z-C6H4OH.

A facile synthesis of 3-phenyl-4-(2-thienyl/2-furyl)- and 3,4-di(2-thienyl)coumarins by phase transfer catalysis method

Synthesis and characterization of 3-phenyl-4-(2-thienyl)coumarins, 4-(2-furyl)-3-phenylcoumarins and 3,4-di(2-thienyl)coumarins have been reported by phase transfer catalysis method in 75% yields. This method involves condensation of appropriate 2-thienyl