3441-41-6

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 106-48-9 4-chloro-phenol 
• 527-72-0 2-thiophenylcarboxylic acid 
• 91059-63-1 4-nitrophenyl 2-thiophenecarboxylic acid ester 

Downstream Products

• 97035-59-1 5-chloro-2-hydroxyphenyl-2-thienylmethanone 
• 97034-92-9 (5-Chloro-2-hydroxy-phenyl)-thiophen-2-yl-methanone oxime 
• 97035-11-5 C₁₃H₁₀ClNO₃S 

Relevant academic research and scientific papers

Reactions of aryl 5-substituted-2-thiophenecarboxylates promoted by 4-Z-C6H4O-/4-Z-C6H4OH in 20 mol % DMSO(aq). Effect of nucleophile on acyl-transfer reaction

Nucleophilic substitution reactions of 5-XC4H2(S)C(O)OC6H3-2-Y-4-NO2 (1) promoted by 4-Z-C6H4O-/4-Z-C6H4OH in 20 mol % dimethyl sulfoxide (DMSO)(aq) have been studied kinetically. The reactions exhibited second-order kinetics with βacyl = -2.52 to -2.83, ρ(x) = 2.81-3.16, βnuc = 0.88-0.04 and βlg = -0.94, respectively. The results have been interpreted with an addition-elimination mechanism in which the nucleophilic attack occurs in the rate-determining step. Comparison with existing data reveals that the ratedetermining step changes from the second to the first step by the change in the nucleophile from R2NH/R2NH2+ to 4-Z-C6H4O-/4-Z-C6H4OH.

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their phenyl esters

A series of m- and p-substituted phenyl benzoates, 2-thienoates, and 2-furoates were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of protons and carbons of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzoates against those of the 2-thienoates and 2-furoates gave an excellent correlation and the values of the slopes are 0.85 and 0.75, respectively, in dimethyl sulfoxide-d6 and 0.90 and 0.78, respectively, in chloroform-d. The values could be considered as a set of aromaticity indices.

A facile synthesis of 3-phenyl-4-(2-thienyl/2-furyl)- and 3,4-di(2-thienyl)coumarins by phase transfer catalysis method

Synthesis and characterization of 3-phenyl-4-(2-thienyl)coumarins, 4-(2-furyl)-3-phenylcoumarins and 3,4-di(2-thienyl)coumarins have been reported by phase transfer catalysis method in 75% yields. This method involves condensation of appropriate 2-thienyl