91059-63-1

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 100-02-7 4-nitro-phenol 
• 527-72-0 2-thiophenylcarboxylic acid 
• 1292766-17-6 copper(I) thiophene-2-carboxylate 
• 62-23-7 4-nitro-benzoic acid 
• 30930-49-5 bis(2-thiophenecarbonyl) peroxide 
• 98-95-3 nitrobenzene 

Downstream Products

• 31330-58-2 (piperidin-1-yl)(thiophen-2-yl)methanone 
• 100-02-7 4-nitro-phenol 
• 349097-59-2 C₁₁H₁₅NOS 
• 52063-83-9 piperazine-1-yl-thiophen-2-yl-methanone 
• 349090-27-3 C₁₁H₁₆N₂O₂S 
• 31330-61-7 morpholin-4-ylthiophen-2-ylmethanone 
• 99580-48-0 C₁₀H₁₂N₂O₂S 
• 881-89-0 phenyl thiophene-2-carboxylate 
• 50514-30-2 4-methoxyphenyl thiophene-2-carboxylate 
• 5402-75-5 4-methylphenyl-2-thiophene carboxylate 
• 3441-41-6 4-chlorophenyl-2-thiophenecarboxylate 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 

Relevant academic research and scientific papers

Decarboxylative Hydroxylation of Benzoic Acids

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme

In this study, we have designed and synthesized 2-((5-acetyl-1-(phenyl)-4-methyl-1H-imidazol-2-yl)thio)-N-(4-((benzyl)oxy)phenyl) acetamide derivatives. Antimicrobial activities of all the imidazole derivatives have been examined against Gram-positive and Gram-negative bacteria and results showed that the conjugates have appreciable antibacterial activity. Besides, several analogous were evaluated for their in vitro antiresistant bacterial strains such as Extended-spectrum beta-lactamases (ESBL), Vancomycin-resistant Enterococcus (VRE), and Methicillin-resistant Staphylococcus aureus (MRSA). The SAR revealed that the 12l compound resulted in potency against all bacterial strains as well as ESBL, VRE, and MRSA strains. Lipinski's rule of five, and ADME studies were preformed for all the synthesized compounds with Staphylococcus aureus dihydropteroate synthase (saDHPS) protein (PDB ID: 6CLV) and were found standard drug-likeness properties of conjugates. Moreover, the binding mode of the ligands with the protein study has been examined by molecular docking and results are quite promising. Besides, all the analogous were tested for their in vitro antituberculosis, antimalarial, and antioxidant activity.

Reactions of 4-nitrophenyl 2-thiophenecarboxylates with R 2NH/R2NH2+ in 20 mol % DMSO (aq). Effects of 5-thienyl substituent and base strength

Reactions of 4-nitrophenyl 2-thiophenecarboxylate (1a-e) with R 2NH/R2NH2+ in 20 mol % DMSO (aq) have been studied kinetically. The 2nd order kinetics, βnuc = 0.88-0.98, and linear Hammett and Yukawa-

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their phenyl esters

A series of m- and p-substituted phenyl benzoates, 2-thienoates, and 2-furoates were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of protons and carbons of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzoates against those of the 2-thienoates and 2-furoates gave an excellent correlation and the values of the slopes are 0.85 and 0.75, respectively, in dimethyl sulfoxide-d6 and 0.90 and 0.78, respectively, in chloroform-d. The values could be considered as a set of aromaticity indices.

Metal Ion Promoted Hydrolysis of p-Nitrophenyl Anthranilates, Glutarate, Salicylate, α-Thiophenate and α-Furoate

The hydrolysis of 4-nitrophenyl anthranilates, salicylate, glutarate, α-thiophenate and α-furoate at pH 9 is first order in , both in the presence and absence of metal ions.The OH(-) ion is considered the most predominant nucleophile under the conditions of the experiments.Ni(II) and Cu(II) ions enhance the rates of hydrolysis.Enhanced metal ion catalysis is observed with increase in buffer concentration.Hammett rho values for the hydrolysis of 4-nitrophenyl anthranilates are +1.7 and +1.1 in the presence and absence of Ni(II) respectively.The metal forms complexes with the esters and OH(-) ion is considered to attack the ester carbonyl of the complexes.No catalysis is observed with Cu(II), Ni(II) or Zn(II) in the hydrolysis of half-esters of succinic, glutaric and diphenic acids.Intramolecular participation of carboxyl group in the removal of phenoxide is probably inhibited in the presence of metal ion which is coordinated to the carbonyl of ester and acid hydroxyl.Stability of ring formed by the metal ion with these esters is partly responsible for the absence of catalysis.