34418-97-8

Upstream product

• 1742-95-6 4-amino-1,8-naphthalimide 
• 100-44-7 benzyl chloride 
• 6492-86-0 4-amino-1,8-naphthalic anhydride 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 

Downstream Products

• 943530-66-3 4-[(2-bromobenzyl)amino]-N-benzyl-1,8-naphthalimide 
• 1032703-85-7 2-benzyl-6-(2-bromo-5-methoxybenzylamino)-benzo[de]isoquinoline-1,3-dione 
• 943530-68-5 4-[(2-bromobenzyl)(methyl)amino]-N-benzyl-1,8-naphthalimide 
• 943530-67-4 4-[benzyl(2-bromobenzyl)amino]-N-benzyl-1,8-naphthalimide 
• 943530-71-0 C₃₂H₃₁BN₂O₄ 
• 943530-69-6 C₃₈H₃₅BN₂O₄ 

Relevant academic research and scientific papers

Fluorescent compound used for APN inhibitor and application of fluorescent compound

The invention discloses a fluorescent compound used for an APN inhibitor and application of the fluorescent compound. The general molecular formula of the compound is (I) or (II). In the general molecular formula, R1is hydrogen, methyl, ethyl, propyl, butyl, amyl, hexyl, benzyl, 2-amino ethyl, 2, 2-N, N-dimethylethyl or hydroxyl; R2 is hydrogen, halogen or a hydrophilic carboxyl group; and R is methyl or ethyl. The inhibitor can be used as an aminopeptidase N inhibitor, and is used for detecting tissue distribution of aminopeptidase N and cancer cells and Doppler tissue imaging; and the inhibitor can be used as an anti-solid tumor medicine, and is used for detection of abnormal expression of aminopeptidase N and disease diagnosis.

Synthesis, evaluation, and computational studies of naphthalimide-based long-wavelength fluorescent boronic acid reporters

Boronic acids that change fluorescence properties upon sugar binding are very useful for the synthesis of carbohydrate sensors. Along this line, boronic acids that fluoresce beyond 500 nm are especially useful. A series of boronic acid fluorescent reporte

Design and synthesis of long-wavelength fluorescent boronic acid reporter compounds

Three new fluorescent probes based on the 4-amino-1,8-naphthalimide structure were synthesized, and their sugar binding properties were studied by using D-fructose, D-glucose and D-sorbitol in 0.1 M phosphate buffer at pH 7.4. All three compounds showed f

Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3, were synthesized and compounds tested for their inhibition of several species of TS. Moreover, their in vitro cytotoxicity together with antimycotic and antibacterial properties were assayed. While no activity was detected in the antibacterial tests, the m-nitro (4ae) and the p-nitro (4af) derivatives were found able to partially inhibit TS at low micromolar concentrations. Introduction of nitro or (substituted)-amino groups in position 4 of the naphthalic ring always led to less active compounds.