344294-32-2Relevant articles and documents
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity
Bernstein, Peter R.,Dang, Xiawei,Devanathan, Sriram,Dorn, Gerald W.,Franco, Antonietta,Fu, Lijun,Walters, Daniel,Williams, Sidney B.
, p. 12506 - 12524 (2021/09/11)
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-c
NEW CHEMISTRY OF ZWITTERIONIC PEROXIDES ARISING BY PHOTOOXYGENATION OF ENOL ETHERS
Jefford, Charles W.,Boukouvalas, John,Kohmoto, Shigeo,Bernardinelli, Gerald
, p. 2081 - 2088 (2007/10/02)
The rose bengal-sensitized photooxygenation of 2-methoxynorborn-2-ene (1) in acetaldehyde gave cis-1-carboxaldehyde-3-carbomethoxycyclopentane (31percent) and the cis and trans-Me derivatives of the cis-fused exo-1,2,4-trioxanes arising by addition of a molecule of oxygen and acetaldehyde to 1 at C3 and C2 respectively (13percent).Similar photooxygenation of 2-(methoxymetylidene)adamantane in the presence of acetaldehyde, propionaldehyde and pivalaldehyde gave adamantanone (31-42percent), and the cis and trans tricyclo3.7>decane-2-spiro-6'- in yields of 32-53percent.Trioxane formation under similar conditions was experienced for 1,1-di-t-butyl-2-methoxyethene and 2-(methylmercaptomethylidene)adamantane.The results are discussed in terms of an intermediate zwitterionic peroxide which can either close directly to a 1,2-dioxetane or, if aldehyde is present, condense across the CO function giving the 1,2,4-trioxane.