344303-47-5Relevant articles and documents
A fluorogenic peptide-based smartprobe for the detection of neutrophil extracellular traps and inflammation
Rios, Maria R.,Garoffolo, Gloria,Rinaldi, Giulia,Megia-Fernandez, Alicia,Ferrari, Silvia,Robb, Calum T.,Rossi, Adriano G.,Pesce, Maurizio,Bradley, Mark
, p. 97 - 100 (2021)
A highly sensitive optical probe for the detection of activated neutrophils and Neutrophil Extracellular Traps (NETs) is reported. It is based on a triple-quenched, super-silent tri-branched probe that generates >20 fold increase in fluorescence upon cleavage. The probe was highly specific for human neutrophil elastase, a protease that mediates a variety of inflammatory diseases, and detected NETosis and neutrophil activation in in vitro differentiated neutrophils and isolated human neutrophils. This journal is