34433-86-8

Basic information

• Product Name: 3-bromopiperidin-2-one
• Synonyms: 3-bromopiperidin-2-one;2-Piperidinone, 3-broMo-;3-bromo-2-Piperidinone
• CAS NO: 34433-86-8
• Molecular Formula: C₅H₈BrNO
• Molecular Weight: 178.02712
• EINECS: 252-023-2
• Mol File: 34433-86-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 147 °C(Solv: acetone (67-64-1))
• Boiling Point: 311.2°Cat760mmHg
• Flash Point: 142°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0.000572mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.94±0.40(Predicted)
• CAS DataBase Reference: 3-bromopiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromopiperidin-2-one(34433-86-8)
• EPA Substance Registry System: 3-bromopiperidin-2-one(34433-86-8)

Safety Data

• Hazardous Substances Data: 34433-86-8(Hazardous Substances Data)

Usage

General Description

3-bromopiperidin-2-one is a chemical compound with the molecular formula C5H8BrNO. It is a white to light yellow solid with a distinct odor. 3-bromopiperidin-2-one is used in the synthesis of various pharmaceuticals and can also act as a building block for organic synthesis. It is a versatile intermediate in organic chemistry and is commonly used in the production of various pharmaceuticals and agrochemicals. 3-bromopiperidin-2-one is a valuable compound in the field of organic synthesis and is widely used in the pharmaceutical industry for the production of various drugs.

InChI:InChI=1/C5H8BrNO/c6-4-2-1-3-7-5(4)8/h4H,1-3H2,(H,7,8)

Upstream product

• 675-20-7 piperidin-2-one 
• 89180-84-7 2,5-Dibromopentanoic Acid Bromide 
• 614754-00-6 2,5-dibromovaleramide 
• 26228-95-5 3,3-dibromopiperidin-2-one 

Downstream Products

• 26228-95-5 3,3-dibromopiperidin-2-one 
• 614754-01-7 2-oxopiperidin-3-yl acetate 
• 49785-74-2 supidimide 
• 42472-96-8 3-phthalimidyl-piperidin-2-one 
• 19365-08-3 3-hydroxypiperidin-2-one 

Relevant articles and documents

Synthesis method of valerolactam alkaloid compound (by machine translation)

The invention discloses a synthesis method, of a valerolactam alkaloid compound. Comprising: 1) reacting thionyl chloride with methanol, then adding ferulic acid, synthesizing ferulic acid methyl ester; 2) reacting 2 -nitrogen hexanone with phosphorus pentachloride; 4) 3, 3 -dibromo -2 - azaltrexone reacts with hydrogen and sodium acetate under the action of potassium iodide to generate 3-bromo 3 -cyclohexanone; 3) reaction, and reacting with hydrogen -2 - and sodium acetate under the action of potassium iodide; and the like 3 -2 . 5) 4) The terpineol prepared in step 3 -) is reacted, with sodium hydroxide, with the terpineol prepared in step -2 2 -) to form a lactam alkaloid compound. The synthetic method has the advantages of accessible raw material sources, mild reaction conditions, and simple reaction process operation. (by machine translation)

Thieno [3, 2 - c] pyridine compound, its preparation method and application

The invention relates to a thieno-[3,2-c] pyridine type compound and an application thereof. The compound has a structure shown by a formula (I) in the specification. The compound of which the structure is shown by the formula (I), provided by the invention has a very good effect of inhibiting the activity of Bruton kinase. The invention also relates to the application of the compound in preventing and/or treating diseases which are improved by virtue of BTK (Bruton tyrosine kinase) activity inhibition.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.