34433-86-8

Usage

Uses

Used in Pharmaceutical Industry:
3-bromopiperidin-2-one is used as a key intermediate for the synthesis of various pharmaceuticals, playing a crucial role in the development of new drugs. Its unique chemical structure allows for the creation of a wide array of medicinal compounds, enhancing the therapeutic options available for treating different diseases and conditions.
Used in Organic Synthesis:
As a versatile building block in organic synthesis, 3-bromopiperidin-2-one is employed for the production of a variety of chemical compounds. Its reactivity and structural properties make it an ideal candidate for use in the synthesis of complex organic molecules, contributing to advancements in the field of chemistry.
Used in Agrochemical Production:
3-bromopiperidin-2-one also finds application in the agrochemical industry, where it is utilized in the synthesis of various agrochemicals. Its use in this sector helps in the development of effective solutions for agricultural challenges, such as pest control and crop protection.

InChI:InChI=1/C5H8BrNO/c6-4-2-1-3-7-5(4)8/h4H,1-3H2,(H,7,8)

Upstream product

• 26228-95-5 3,3-dibromopiperidin-2-one 
• 675-20-7 piperidin-2-one 
• 89180-84-7 2,5-Dibromopentanoic Acid Bromide 
• 614754-00-6 2,5-dibromovaleramide 

Downstream Products

• 42472-96-8 3-phthalimidyl-piperidin-2-one 
• 614754-01-7 2-oxopiperidin-3-yl acetate 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 26228-95-5 3,3-dibromopiperidin-2-one 
• 49785-74-2 supidimide 

Relevant academic research and scientific papers

Synthesis method of valerolactam alkaloid compound (by machine translation)

The invention discloses a synthesis method, of a valerolactam alkaloid compound. Comprising: 1) reacting thionyl chloride with methanol, then adding ferulic acid, synthesizing ferulic acid methyl ester; 2) reacting 2 -nitrogen hexanone with phosphorus pentachloride; 4) 3, 3 -dibromo -2 - azaltrexone reacts with hydrogen and sodium acetate under the action of potassium iodide to generate 3-bromo 3 -cyclohexanone; 3) reaction, and reacting with hydrogen -2 - and sodium acetate under the action of potassium iodide; and the like 3 -2 . 5) 4) The terpineol prepared in step 3 -) is reacted, with sodium hydroxide, with the terpineol prepared in step -2 2 -) to form a lactam alkaloid compound. The synthetic method has the advantages of accessible raw material sources, mild reaction conditions, and simple reaction process operation. (by machine translation)

PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

Disclosed in the present invention are a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and also disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

Thieno [3, 2 - c] pyridine compound, its preparation method and application

The invention relates to a thieno-[3,2-c] pyridine type compound and an application thereof. The compound has a structure shown by a formula (I) in the specification. The compound of which the structure is shown by the formula (I), provided by the invention has a very good effect of inhibiting the activity of Bruton kinase. The invention also relates to the application of the compound in preventing and/or treating diseases which are improved by virtue of BTK (Bruton tyrosine kinase) activity inhibition.

Xanthone receptors as oxyanion-hole mimics in artificial enzymes

Different xanthone-based receptors (2-10) for lactones and lactams have been prepared, and the feasibility of these compounds to mimic the known enzymatic 'oxyanion-hole' structure is discussed. The self-association of the receptors was found to pose a serious drawback for complex formation. X-Ray crystal structures of receptor dimers allowed us to understand the reasons for their self-association and to improve the design of the catalysts. The catalytic activity of the receptors has been tested towards the nucleophilic addition of pyrrolidine to unsaturated lactones. Since the resulting complexes were very weak in organic solvents, new receptors were developed for lactams, which showed better stabilities, and their catalytic activities were studied.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.

Aminothiazole Derivatives. II. A Facile Synthesis of Condensed 4-Aminothiazole Derivatives using α-Bromolactams and Thioamides

The reaction of an α-bromolactam with a thioamide was found to give a cyclic 4-aminothiazole derivative.Novel heterocyclic compounds such as 4,5,6,7-tetrahydrothiazolopyridines 10, 5,6,7,8-tetrahydro-4H-thiazoloazepines 11, 4,5,6,7,8,9-hexahydrothiazoloazocine 12 and 9,10-dihydro-4H-thiazolobenzazepines 18 were thus prepared and the utility of this method in the construction of 4-aminothiazole-containing compounds was suggested.